氧化苦参碱(98%, HPLC)
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产品编号 SM4048-10mM
数量
¥ 73.00
产品包装:
10mM×0.2ml 25mg 100mg
产品简介
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化学信息:
中文名 氧化苦参碱
英文名 Oxymatrine
中文别名 -
英文别名 Matrine N-oxide;Oxysophoridine
来源 越南槐Sophora tonkinensis Gagnep.;苦参Sophora flavescens Alt.
化合物类型 生物碱(Alkaloids)>喹诺里西啶类生物碱
化学式 C15H24N2O2
分子量 264.36
CAS号 16837-52-8
纯度 98%, HPLC
溶剂/溶解度 DMSO:100 mg/mL (378.27 mM);
Water:100 mg/mL (378.27 mM)
溶液配制 3mg加入1.13ml DMSO,或者每2.64mg加入1ml DMSO,配制成10mM溶液。

生物信息
产品描述 Oxymatrine, an alkaloid from the roots of Sophora species, with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. Oxymatrine inhibits bocavirus minute virus of canines (MVC) replication, reduces viral gene expression and decreases apoptosis induced by viral infection.
信号通路 TGF-beta/Smad
靶点 iNOS MVC - - -
IC50 - - - - -
体外研究 Oxymatrine, an alkaloid component extracted from the roots of Sophora species, has been shown to have antiinflammatory, antifibrosis, and antitumor effects and the ability to protect against myocardial damage, etc. The potential signaling pathways involved in the clinical application of oxymatrine might include the TGF-β/Smad, tolllike receptor 4/nuclear factor kappa-light-chain-enhancer of activated B cells, toll-like receptor9/TRAF6, Janus kinase/signal transduction and activator of transcription, phosphatidylinositol-3 kinase/Akt, delta-opioid receptorarrestinl-Bcl-2, CD40, epidermal growth factor receptor, nuclear factor erythroid-2-related factor 2/hemeoxygenase-1 signaling pathways, and dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine metabolism pathway. Oxymatrine significantly inhibits the proliferation of DU145 and PC-3 cell lines in a time- and dose-dependent manner. By contrast, following treatment with oxymatrine, PNT1B healthy human prostate cell proliferation is not inhibited.
体内研究 The volume and weight of tumors in mice significantly decreased in a dose-dependent manner. Oxymatrine may reduce prostate cancer cell growth by promoting cell apoptosis in vivo. Oxymatrine is effective in reducing the production and deposition of collagen in the liver tissue of experimental rats. Oxymatrine could promote the expression of Smad 7 and inhibit the expression of Smad 3 and CBP in CCl4-induced hepatic fibrosis in SD rats, could modulate the fibrogenic signal transduction of TGFβ-Smad pathway.
临床实验 N/A
参考文献:

1.Lu ML, et al. Phytother Res. 2016,30(7):1104-12.

2.Wu C, et al. Mol Med Rep. 2015,11(6):4129-34.

3.Wu XL, et al. World J Gastroenterol. 2008,14(13):2100-5.

4.Ding Y, et al. Virol Sin. 2019,34(1):78-87.

包装清单:
产品编号 产品名称 包装
SM4048-10mM 氧化苦参碱(98%, HPLC) 10mM×0.2ml
SM4048-25mg 氧化苦参碱(98%, HPLC) 25mg
SM4048-100mg 氧化苦参碱(98%, HPLC) 100mg
说明书 1份
保存条件:

-20℃保存,至少一年有效。固体粉末4℃保存,至少一个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。

注意事项:

本产品可能对人体有一定的毒害作用,请注意适当防护,以避免直接接触人体或吸入体内。

本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。

为了您的安全和健康,请穿实验服并戴一次性手套操作。

使用说明:
1.收到产品后请立即按照说明书推荐的条件保存。使用前可以在2,000-10,000g离心数秒,以使液体或粉末充分沉降至管底后再开盖使用。
2.对于10mM溶液,可直接稀释使用。对于固体,请根据本产品的溶解性及实验目的选择相应溶剂配制成高浓度的储备液(母液)后使用。
3.具体的最佳工作浓度请参考本说明书中的体外、体内研究结果或其它相关文献,或者根据实验目的,以及所培养的特定细胞和组织,通过实验进行摸索和优化。
4.不同实验动物依据体表面积的等效剂量转换表请参考如下网页:
https://www.beyotime.com/support/animal-dose.htm
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