| 中文名 | 异欧前胡素 |
| 英文名 | Isoimperatorin |
| 中文别名 | 白芷甲素；异欧芹属素乙 |
| 英文别名 | - |
| 来源 | 羌活Notopterygium incisum Ting ex H. T. Chang；白芷Angelica dahurica （Fisch. ex Hoffm.）Benth. et Hook. f. ex Franch. et Sav |
| 化合物类型 | 苯丙素类(Phenylpropanoids)＞香豆素类(Coumarins)>线型呋喃香豆素 |
| 化学式 | C16H14O4 |
| 分子量 | 270.28 |
| CAS号 | 482-45-1 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
Ethanol: 8.33 mg/ml (30.82 mM); DMSO: 2.5 mg/ml (9.25 mM; ultrasonic and warming and heat to 60°C) |
| 溶液配制 | 5mg加入1.85ml 乙醇，或者每2.70mg加入1ml 乙醇，配制成10mM溶液。 |
| 产品描述 | Isoimperatorin is a methanolic extract of the roots of Angelica dahurica shows significant inhibitory effects on acetylcholinesterase (AChE) with the IC50 of 74.6 μM. | ||||
| 信号通路 | - | ||||
| 靶点 | AChE | B. xylophilus | - | - | - |
| IC50 | 74.6 μM | 21.83 μg/ml | - | - | - |
| 体外研究 | During a screening program for new agrochemicals from Chinese medicinal herbs, the ethanol extract of Notopterygium incisum rhizomes is found to possess strong nematicidal activity against the two species of nematodes, Bursaphelenchus xylophilus and Meloidogyne incognita. Based on bioactivity-guided fractionation, the four constituents are isolated from the ethanol extract and identified as Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin. Isoimperatorin also has LC50 values of 21.83 μg/ml against B. xylophilus. When using 15 min UV light treatment, falcarindiol, falcarinol, and isoimperatorin demonstrated almost five times more toxic to the southern root-knot nematodes than in dark treatment while columbianetin showed only two times more toxic. isoimperatorin has been demonstrated to possess insecticidal activity against several insects, such as the cabbage aphid (Brevicoryne brassicae). Isoimperatorin is identified in the active fraction of Angelica dahurica (AD) extract. Isoimperatorin is usually used as the internal standard (IS). | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1.Kim DK, et al. Arch Pharm Res. 2002,25(6):856-9.
2.Liu G, et al. Molecules. 2016,21(10):1276.
3.Park EY, et al. PLoS One. 2016,11(7):e0158796.
4.Yu XA, et al. Chem Cent J. 2016,10:62.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1160-25mg | 异欧前胡素(98%, HPLC) | 25mg |
| SM1160-100mg | 异欧前胡素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
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