| CAS Number | Chemical Formula | Molecular Weight | Purity | Grade |
| 85622-93-1 | C6H6N6O2 | 194.15 | ≥98% | Reagent grade |
基本信息(General Information):
| Name (Chinese) | 替莫唑胺 |
|
| Name (English) | Temozolomide | |
| Specifications | Reagent grade, ≥98% (HPLC) | |
| Synonym (Chinese) | 3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺, 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺, 4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺, 8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮, NSC 362856 | |
| Synonym (English) | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide; 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2 | |
| Beilstein Registry No | - | |
| EINECS Number | - | |
| MDL Number | MFCD00866492 | |
| UNSPSC Code | 12352200 |
产品描述(Description):
| Application | 替莫唑胺已可用于分析胶质母细胞瘤细胞系的耐药机制15，16。 |
| Biochem/physiol Actions | 替莫唑胺是一种DNA甲基化剂和耐药修饰剂；抗肿瘤和抗血管生成。替莫唑胺诱导G2/M阻滞和凋亡，原理是其通过基因组DNA中一个甲基基团内收至鸟嘌呤的O6位置，以及碱基切除修复(BER)途径中DNA修复蛋白O(6)-烷基鸟嘌呤DNA烷基转移酶(AGT)的功能失活。 |
| Preparation Note | 替莫唑胺溶于DMSO，溶解浓度大于20 mg/ml。它不溶于水。 |
性质(Properties)：
| assay | >=98% (HPLC) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10 mg/mL, clear |
| solubility | H2O: insoluble |
| form | powder |
| color | white to light brown |
安全信息(Safety Information)：
| Hazard Pictogram Codes |
 
|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H319-H335-H350-H360 |
| Precautionary Statements | P201-P261-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes (Europe) | T |
| Risk Codes (Europe) | 45-46-60-61-22-36/37/38 |
| Safety Codes (Europe) | 53-26-36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NJ5927050 |
| Flash Point (F) | - |
| Flash Point (C) | - |
包装清单:
| 产品编号 | 产品名称 | 包装 |
| ST1695-5mg | 替莫唑胺(≥98%, Reagent grade) | 5mg |
| ST1695-25mg | 替莫唑胺(≥98%, Reagent grade) | 25mg |
| ST1695-100mg | 替莫唑胺(≥98%, Reagent grade) | 100mg |
| － | 说明书 | 1份 |
保存条件:
4°C保存，三年有效。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
