| CAS Number | Chemical Formula | Molecular Weight | Purity | Grade |
| 28822-58-4 | C10H14N4O2 | 222.24 | ≥99% | Reagent grade |
基本信息(General Information):
| Name (Chinese) | IBMX |
|
| Name (English) | IBMX|3-Isobutyl-1-methylxanthine | |
| Specifications | Reagent grade, ≥99% (HPLC), powder | |
| Synonym (Chinese) | 3-异丁基-1-甲基黄嘌呤, 1-甲基-3-异丁基黄嘌呤, 3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮, 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮 | |
| Synonym (English) | 1-Methyl-3-isobutylxanthine; 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione; 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione; IBMX | |
| Beilstein Registry No | 247859 | |
| EINECS Number | 249-259-3 | |
| MDL Number | MFCD00005584 | |
| UNSPSC Code | 12352202 |
产品描述(Description):
| Biochem/physiol Actions | cAMP和cGMP磷酸二酯酶的非特异性抑制剂。由IBMX的磷酸二酯酶抑制引起的cAMP水平的增加激活PKA，导致增殖减少，分化增加和凋亡诱导。IBMX抑制去氧肾上腺素诱导的来自气道粘膜神经内分泌上皮细胞的5-羟色胺的释放(IC50：1.3μM)。 也用作腺苷受体拮抗剂。显示出抑制神经肌肉接头，GH3细胞和血管平滑肌细胞中的离子通道。诱导细胞内存储在感觉神经元中释放钙。 |
性质(Properties)：
| assay | >=99% (HPLC) |
| storage temp. | -20°C |
| mp | 200-201°C(lit.) |
| solubility | DMSO: soluble1 M (with gentle warming) |
| solubility | ethanol: soluble10 mg/mL |
| Gene Information | human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)rat ... Adora1(29290), Adora2a(25369) |
| form | powder |
| color | white to off-white |
安全信息(Safety Information)：
| Hazard Pictogram Codes |
|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | - |
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes (Europe) | Xn |
| Risk Codes (Europe) | 22 |
| Safety Codes (Europe) | - |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | ZD8500000 |
| Flash Point (F) | - |
| Flash Point (C) | - |
包装清单:
| 产品编号 | 产品名称 | 包装 |
| ST1398-50mg | IBMX (≥99%, Reagent grade) | 50mg |
| ST1398-250mg | IBMX (≥99%, Reagent grade) | 250mg |
| ST1398-1g | IBMX (≥99%, Reagent grade) | 1g |
| － | 说明书 | 1份 |
保存条件:
-20°C保存，两年有效。
注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
