化学信息：
| 中文名 | 知母皂苷BII |
| 英文名 | Timosaponin BII |
| 中文别名 | - |
| 英文别名 | Prototimosaponin A III |
| 来源 | 知母Anemarrhena asphodeloides Bunge |
| 化合物类型 | 甾体类(Steroids)>甾体皂苷 |
| 化学式 | C45H76O19 |
| 分子量 | 921.08 |
| CAS号 | 136656-07-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/ml (108.6 mM) |
| 溶液配制 | 10mg加入1.09ml DMSO，或者每9.21mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Timosaponin BII is a steroid saponin found in the rhizomes of Anemarrhena asphodeloides. Timosaponin BII has neuronal protective and anti-inflammatory effects and antioxidant property. | ||||
| 信号通路 | Inflammation | ||||
| 靶点 | BACE1 | MDA | Aβ1-40 | β-CTF | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/ml in the HL-60 cells. | ||||
| 体内研究 | Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time. | ||||
| 临床实验 | N/A | ||||
1. Guo J, et al. Arch Pharm Res. 2015,38(5):598-603.
2. Huang JF, et al. BMC Complement Altern Med. 2012,12:189.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM7028-10mM | 知母皂苷BII (98%, HPLC) | 10mM×0.2ml |
| SM7028-5mg | 知母皂苷BII (98%, HPLC) | 5mg |
| SM7028-25mg | 知母皂苷BII (98%, HPLC) | 25mg |
| SM7028-100mg | 知母皂苷BII (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
