化学信息：
| 中文名 | 竹节参皂苷ⅣA |
| 英文名 | Chikusetsusaponin IVA |
| 中文别名 | - |
| 英文别名 | Calenduloside F |
| 来源 | 珠子参Panax japonicus var. major (Burkill) C. Y. Wu & K. M. Feng；竹节参Panax japonicus (T. Nees) C. A. Mey. |
| 化合物类型 | 萜类(Terpenoids)>三萜>齐墩果烷型五环三萜皂苷 |
| 化学式 | C42H66O14 |
| 分子量 | 794.97 |
| CAS号 | 51415-02-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (125.79 mM) |
| 溶液配制 | 10mg加入1.26ml DMSO，或者每7.95mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Chikusetsusaponin IVa a major active ingredient of triterpenoid saponins, exerts antithrombotic effects, including minor hemorrhagic events. This appears to be important for the development of new therapeutic agents. A novel AMPK activator that is capable of bypassing defective insulin signalling and could be useful for the treatment of T2DM or other metabolic disorders. | ||||
| 信号通路 | NF-κB; ERK; JNK; p38 | ||||
| 靶点 | Fibrinogen Clotting | Thrombin | AMPK | - | - |
| IC50 | 199.4 ± 9.1 μM | 219.6 μM | - | - | - |
| 体外研究 | Using biochemical and pharmacological methods, it proves that chikusetsusaponin IVa prolongs the recalcification time, prothrombin time, activated partial thromboplastin time, and thrombin time of normal human plasma in a dose-dependent manner; inhibits the amidolytic activity of thrombin and factor Xa upon synthetic substrates S2238 and S2222; inhibits thrombin-induced fibrinogen clotting (50% inhibition concentration, 199.4 ± 9.1 μM); inhibits thrombin- and collagen-induced platelet aggregation. Chikusetsusaponin IVa can also preferentially inhibits thrombin in a competitive manner (K(i)=219.6 μM). Chikusetsusaponin IVa suppresses the production of iNOS, COX-2, IL-1β, IL-6, and TNF-α in LPS-stimulated THP-1 cells likely by inhibiting NF-κB activation and ERK, JNK, and p38 signal pathway phosphorylation. | ||||
| 体内研究 | Studies were performed on type 2 diabetic mellitus (T2DM) rats given CHS for 28 days to test the antihyperglycemic activity. Oral administration of CHS dose-dependently increased the level of serum insulin and decreased the rise in blood glucose level. | ||||
| 临床实验 | N/A | ||||
1. Wang H, et al. Int J Immunopathol Pharmacol. 2015,28(3):308-17.
2. Cui J, et al. J Ethnopharmacol. 2015,164:334-9.
3. Li Y, et al. J Pharm Pharmacol. 2015,67(7):997-1007.
4. Dahmer T, et al. J Med Food. 2012,15(12):1073-80.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6124-10mM | 竹节参皂苷ⅣA (98%, HPLC) | 10mM×0.2ml |
| SM6124-5mg | 竹节参皂苷ⅣA (98%, HPLC) | 5mg |
| SM6124-25mg | 竹节参皂苷ⅣA (98%, HPLC) | 25mg |
| SM6124-100mg | 竹节参皂苷ⅣA (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
