化学信息：
| 中文名 | 酸枣仁皂苷A |
| 英文名 | Jujuboside A |
| 中文别名 | - |
| 英文别名 | Arecoline Hydrobromide |
| 来源 | 酸枣Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow；枣Ziziphus jujuba Mill. |
| 化合物类型 | 萜类(Terpenoids)>三萜>达玛烷型四环三萜皂苷 |
| 化学式 | C58H94O26 |
| 分子量 | 1207.35 |
| CAS号 | 55466-04-1 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 82.8 mM; Water: 50 mg/ml (41.41 mM) |
| 溶液配制 | 15mg加入1.24ml DMSO，或者每12.07mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Jujuboside A is a glycoside extracted from Semen Ziziphi Spinosae, a Chinese herbal medicine used to treat insomnia and anxiety. | ||||
| 信号通路 | - | ||||
| 靶点 | GABA Receptor | mTOR | PI3K | Akt | - |
| IC50 | 41 μM | - | - | - | - |
| 体外研究 | Jujuboside A at the low dose of 41 μM (about 0.05 g/L) induces significant increase of GABA(A) receptor α1, α5, β2 subunit mRNAs in both 24 and 72h treatments. Jujuboside A at the high dose of 82 μM (about 0.1 g/L) significantly increases GABA(A) receptor α1, α5 subunit mRNA levels and decreases β2 subunit mRNA level at 24h treatment, and decreases GABA(A) receptor subunit α1, β2 mRNAs expression at 72h treatment. Jujuboside A pretreatment could reverse the reduction of cell viability and better the injury of H9C2 cells induced by ISO. Jujuboside A could accelerate the phosphorylation of PI3K, Akt, and mTOR. Jujuboside A could significantly decrease the ratio of microtubule-associated protein LC3-II/I in H9C2 cells. | ||||
| 体内研究 | During daytime (9:00-15:00), jujubosides significantly increases the total sleep and rapid eye movement (REM) sleep without significant influence on non-REM (NREM) sleep. During nighttime (21:00-3:00), jujubosides significantly increases the total sleep and NREM sleep especially the light sleep while shows no significant effect on REM sleep and slow wave sleep (SWS). Intracerebroventricular treatment with Jujuboside A significantly mitigates learning and memory impairment in mice induced by Aβ1–42 as measured by the Y-maze, active avoidance and Morris water maze. Intracerebroventricular treatment with Jujuboside A reduces the level of Aβ1–42 in hippocampus, significantly inhibits the activities of acetylcholinesterase (AChE) and NO, and decreases the amount of the increased malondialdehyde (MDA) in the hippocampus and cerebral cortex of mice treated with intracerebroventricular injection of Aβ1–42. | ||||
| 临床实验 | N/A | ||||
1. You ZL, et al. J Ethnopharmacol. 2010,128(2):419-23.
2. Han D, et al. Evid Based Complement Alternat Med. 2016:9593716.
3. Cao JX, et al. J Ethnopharmacol. 2010,130(1):163-6.
4. Liu Z, et al. Eur J Pharmacol. 2014,738:206-13.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6048-10mM | 酸枣仁皂苷A (98%, HPLC) | 10mM×0.2ml |
| SM6048-5mg | 酸枣仁皂苷A (98%, HPLC) | 5mg |
| SM6048-25mg | 酸枣仁皂苷A (98%, HPLC) | 25mg |
| SM6048-100mg | 酸枣仁皂苷A (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
