化学信息：
| 中文名 | 紫云英苷 |
| 英文名 | Astragalin |
| 中文别名 | 紫云英甙；黄芪苷；山奈酚-3-葡萄糖苷 |
| 英文别名 | Astragaline; 3-Glucosylkaempferol; Kaempferol 3-β-D-glucopyranoside |
| 来源 | 臭冷杉Abies nephrolepis，六角莲Dysosma pleiantha [Syn. Podophyllum pleianthum]；落地生根Bryophyllum pinnatum，毛叶石楠Photinia lactiflora |
| 化合物类型 | 黄酮类化合物 |
| 化学式 | C21H20O11 |
| 分子量 | 448.38 |
| CAS号 | 480-10-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 4.48mg/ml (10 mM) |
| 溶液配制 | 5mg加入1.12ml DMSO，或者每4.48mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Astragalin, a flavonoid from leaves of persimmon and green tea seeds, has anti-tumor, anti-inflammatory and anti-oxidant activities. | ||||
| 信号通路 | - | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Astragalin suppressed cellular induction of Toll-like receptor 4 (TLR4) and ROS production enhanced by LPS. H2O2-upregulated phosphorylation of JNK and p38 MAPK was dampened by adding astragalin to epithelial cells, while this compound enhanced epithelial activation of Akt and ERK. H2O2 and LPS promoted epithelial apoptosis, which was blunted by astragalin [1]. Astragalin suppressed the expression of TNF α, IL- 6, and nitric oxide in a dose-dependent manner in mMECs [2]. Astragalin attenuated the infiltration of inflammatory cells, the activity of MPO and the expression of TNF-α, IL-6 and IL-1β in a dose-dependent manner. Additionally, Astragalin efficiently blunt decreased nuclear factor-kappaB (NF-κB) activation by inhibiting the degradation and phosphorylation of IκBα and the nuclear translocation of p65 [3]. Astragalin significantly reduced LPS-induced expression of iNOS, COX-2 and cytokines/chemokines, and production of NO in J774A.1 mouse macrophages. [4]. | ||||
| 体内研究 | Mice were injected intraperitoneally (i.p.) with lipopolysaccharide (LPS) (dose range: 5-40 mg/kg). pretreatment with astragalin can improve survival during lethal endotoxemia and attenuate inflammatory responses in a murine model of lipopolysaccharide-induced acute lung injury [4] | ||||
| 临床实验 | |||||
1. Cho IH, et al. BMC Pulm Med. 2014 Jul 29;14:122.
2. Li F, et al. J Surg Res. 2014 Dec;192(2):573-81.
3. Li F, et al.Int Immunopharmacol. 2013 Oct;17(2):478-82.
4. Kim MS, et al.Arch Pharm Res. 2011 Dec;34(12):2101-7.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4176-10mM | 紫云英苷(98%, HPLC) | 10mM×0.2ml |
| SM4176-5mg | 紫云英苷(98%, HPLC) | 5mg |
| SM4176-25mg | 紫云英苷(98%, HPLC) | 25mg |
| SM4176-100mg | 紫云英苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
