化学信息：
| 中文名 | 靛玉红 |
| 英文名 | Indirubin |
| 中文别名 | - |
| 英文别名 | Couroupitine B; Indigo red; Indigopurpurin |
| 来源 | 蓼蓝Polygonum tinctorium Ait.；菘蓝Isatis indigotica Fortune |
| 化合物类型 | 生物碱(Alkaloids)>吲哚类 |
| 化学式 | C16H10N2O2 |
| 分子量 | 262.26 |
| CAS号 | 479-41-4 |
| 纯度 | 97%, HPLC |
| 溶剂/溶解度 | DMSO: 10 mg/ml (38.13 mM) |
| 溶液配制 | 5mg加入1.91ml DMSO，或者每2.63mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Indirubin (Couroupitine B) is a purple 3,2- bisindole and a stable isomer of indigo isolated from Indigo naturalis (Apiaceae); anti-inflammatory and anticancer activities. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | EGF Receptor | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | The activation of EGF receptor, known to be highly expressed in psoriatic lesions, was inhibited by indigo naturalis or indirubin. The cell proliferation and CDC25B expression of epidermal keratinocytes were induced by EGF alone and confirmed to be inhibited by indigo naturalis or indirubin. Indirubin inhibited prostate tumor growth through inhibiting tumor angiogenesis. Indirubin inhibited angiogenesis in vivo. We also showed the inhibition activity of indirubin in endothelial cell migration, tube formation and cell survival in vitro. | ||||
| 体内研究 | Indirubin treatment suppressed skin inflammation in DNCB-exposed mice. The skin lesions were significantly thinner in the Indirubin-treated group than in untreated controls, and the hyperkeratosis disappeared. Indirubin reduced the total serum IgE level and cytokines production. In addition, it normalized NF-κB, IκB-α and MAP kinase expression. Indirubin dose-dependently inhibited intersegmental vessel formation in zebrafish embryos. It also inhibited HUVEC proliferation by the induction of cellular apoptosis and cell-cycle arrest at the G0/G1 phase. | ||||
| 临床实验 | NCT01735864: Psoriasis Vulgaris, Not Applicable. | ||||
1. Kim MH, et al. J Ethnopharmacol. 2013,145(1):214-9.
2. Hsieh WL, et al. J Dermatol Sci. 2012,67(2):140-6.
3. Zhang X, et al. Int J Cancer. 2011,129(10):2502-11.
4. Alex D, et al. J Ethnopharmacol. 2010,131(2):242-7.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4172-10mM | 靛玉红(97%, HPLC) | 10mM×0.2ml |
| SM4172-5mg | 靛玉红(97%, HPLC) | 5mg |
| SM4172-25mg | 靛玉红(97%, HPLC) | 25mg |
| SM4172-100mg | 靛玉红(97%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
