化学信息：
| 中文名 | 原阿片碱 |
| 英文名 | Protopine |
| 中文别名 | 双花母草素；全能花素 |
| 英文别名 | Fumarine; Corydalis C; Corydinine; Biflorine; Macleyine |
| 来源 | 伏生紫堇Coydalis decumbens (Thunb.) Pers.；延胡索Corydalis yanhusuo (Y.H.Chou & Chun C.Hsu) W.T.Wang ex Z.Y.Su & C.Y.Wu |
| 化合物类型 | 生物碱(Alkaloids)>异喹啉类生物碱 |
| 化学式 | C20H19O5 |
| 分子量 | 353.37 |
| CAS号 | 130-86-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 12.5 mg/ml (35.37 mM) |
| 溶液配制 | 5mg加入1.41ml DMSO，或者每3.53mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Protopine, an isoquinoline alkaloid contained in plants in northeast Asia. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | COX-2 | PGE(2) | NO | Cdk1 | Bcl-2 |
| IC50 | - | - | - | - | - |
| 体外研究 | Protopine was found to reduce nitric oxide (NO), cyclooxygenase-2 (COX-2), and prostaglandin E(2) (PGE(2)) production by LPS-stimulated Raw 264.7 cells, without a cytotoxic effect. Pre-treatment of Raw 264.7 cells with protopine reduced the production of pro-inflammatory cytokines. Protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins. In HepG2 cells, protopine significantly increased CYP1A1 mRNA levels after 24h exposure at concentrations from 25 and 10 μM. Protopine also dose-dependently increased CYP1A1 and CYP1A2 mRNA levels in human hepatocytes. | ||||
| 体内研究 | Assays were performed on MDA-MB-231 human breast cancer cells, and the result showed that protopine exhibited anti-adhesive and anti-invasion effects in MDA-MB-231 cells; after treatment with protopine for 90 min, the expression of EGFR, ICAM-1, αv-integrin, β1-integrin and β5-integrin were remarkably reduced. | ||||
| 临床实验 | N/A | ||||
1. Bae DS, et al. BMB Rep. 2012,45(2):108-13.
2. Chen CH, et al. Cancer Lett. 2012,315(1):1-11.
3. Vrba J, et al. Toxicol Lett. 2011,203(2):135-41.
4. He K, et al. Afr J Tradit Complement Altern Med. 2014,11(2):415-24. 包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4088-10mM | 原阿片碱(98%, HPLC) | 10mM×0.2ml |
| SM4088-5mg | 原阿片碱(98%, HPLC) | 5mg |
| SM4088-25mg | 原阿片碱(98%, HPLC) | 25mg |
| SM4088-100mg | 原阿片碱(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
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