化学信息：
| 中文名 | 盐酸益母草碱 |
| 英文名 | Leonurine Hydrochloride |
| 中文别名 | 益母草碱盐酸盐 |
| 英文别名 | SCM-198 hydrochloride; SCM-198 HCl |
| 来源 | 益母草Leonurus japonicus Houtt. |
| 化合物类型 | 生物碱(Alkaloids) |
| 化学式 | C14H22ClN3O5 |
| 分子量 | 347.79 |
| CAS号 | 24735-18-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 31 mg/ml (89.13 mM); Water: 5 mg/ml (14.38 mM) |
| 溶液配制 | 5mg加入1.44ml DMSO，或者每3.48mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. | ||||
| 信号通路 | Autophagy; AMPK/SREBP1; PI3K/Akt | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner. | ||||
| 体内研究 | Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model. | ||||
| 临床实验 | N/A | ||||
1. Jiang T, et al. Cell Physiol Biochem. 2017,43(4):1703-1717.
2. Zhang L, et al. Biomed Pharmacother. 2018,110:571-581.
3. Hu ZC, et al. J Cell Physiol. 2019,234(5):6940-6950.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4016-10mM | 盐酸益母草碱(98%, HPLC) | 10mM×0.2ml |
| SM4016-5mg | 盐酸益母草碱(98%, HPLC) | 5mg |
| SM4016-25mg | 盐酸益母草碱(98%, HPLC) | 25mg |
| SM4016-100mg | 盐酸益母草碱(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
