化学信息：
| 中文名 | 左旋紫草素 |
| 英文名 | Alkannin |
| 中文别名 | - |
| 英文别名 | (-)-Shikonin; Shikalkin |
| 来源 | 紫草Lithospermum erythrorhizon Sieb. et Zucc. |
| 化合物类型 | 醌类(Quinones)>α-(1,4)萘醌 |
| 化学式 | C16H16O5 |
| 分子量 | 288.3 |
| CAS号 | 517-88-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 33 mg/ml (115.61 mM) |
| 溶液配制 | 5mg加入1.73ml DMSO，或者每2.88mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Alkannin, found in Alkanna tinctoria, is used as a food coloring. Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. Alkannin improves hepatic inflammation in a Rho-kinase pathway. | ||||
| 信号通路 | - | ||||
| 靶点 | TLR2 | NF-κB | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Alkannin inhibits HCT-116 and SW-480 cells growth with IC50s of 2.38 and 4.53 µM, respectively.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cell viability and adhesion ability of MGC-803 cells. Cell scratch repair experiments were conducted for the determination of migration ability while transwell assay for cell invasion ability. Western blot analysis and real-time polymerase chain reaction assay were used for the detection of protein and mRNA expressions. Fifty per cent inhibitory concentration of Shikonin on MGC-803 cells was 1.854 μm. Shikonin (1 μm) inhibited significantly the adhesion, invasion and migratory ability of MGC-803 cells. Interestingly, Shikonin in the presence or absence of anti-Toll-like receptor 2 (TLR2) antibody (2 μg) and nuclear factor-kappa B (NF-κB) inhibitor MG-132 (10 μm) could decrease these ability of MGC-803 cells markedly, as well as the expression levels of matrix metalloproteinases (MMP)-2, MMP-7, TLR2 and p65 NF-κB. In addition, the co-incubation of Shikonin and anti-TLR2/MG-132 has a significant stronger activity than anti-TLR2 or MG-132 alone. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1. Hosokawa Y, et al. Cell Biol Int. 2016,40(12):1380-1385.
2. Huu Tung N, et al. Phytother Res. 2013,27(1):66-70.
3. Xue W, et al. Cell Physiol Biochem. 2018,45(6):2461-2470.
包装清单：
| 产品编号 | 产品名称 | 包装 |
| SM3005-10mM | 左旋紫草素(98%, HPLC) | 10mM×0.2ml |
| SM3005-5mg | 左旋紫草素(98%, HPLC) | 5mg |
| SM3005-25mg | 左旋紫草素(98%, HPLC) | 25mg |
| SM3005-100mg | 左旋紫草素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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