化学信息：
| 中文名 | 蔓荆子黄素 |
| 英文名 | Casticin |
| 中文别名 | 紫花牡荆素 |
| 英文别名 | Vitexicarpin |
| 来源 | 蔓荆Vitex trifolia L.；黄花蒿Artemisia annua Linn.；母菊Matricaria recutita L. |
| 化合物类型 | 黄酮类(Flavonoids)>黄酮>黄酮醇 |
| 化学式 | C19H18O8 |
| 分子量 | 374.34 |
| CAS号 | 479-91-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 10 mg/mL (26.7 mM) |
| 溶液配制 | 5mg加入1.34ml DMSO，或者每3.74g加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Casticin is a methyoxylated flavonol isolated from Viticis Fructus, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3. | ||||
| 信号通路 | Inflammation | ||||
| 靶点 | STAT3 | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Casticin (0.2-1.0 μM) dose-dependently inhibits the proliferation of KB cells, with an IC50 of 0.23 μM on day 3, while shows no significant inhibition on 3T3 Swiss Albino and TIG-103 cells. Casticin (0.6 μM) alters spindle morphology with partial mitotic spindle breakdown or with disordered spindles. Casticin (0-40 μM) dose-dependently inhibits the proliferation of LX2 cells. Casticin (40 μM) suppresses L02 cells proliferation and induces apoptosis. Casticin inhibits fibrotic effects of TGF-β1 on ECM deposition in LX2 cells by evaluating the mRNA levels of TGF-β, collagen α1(I), MMP-2, MMP-9, TIMP-1 and TIMP-2. Casticin (0-8 μM) reduces the viability of 786-O, YD-8, and HN-9 cells, but shows no significant effect on that of the normal HEL 299 cells. Casticin (5 μM) increases cleavage caspase-3 and PPAR, diminishes the levels of B-cell lymphoma-extra large (Bcl-xl), Bcl-2, IAP-1/-2, vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9), and cyclooxygenase 2 (COX-2) proteins in 786-O, YD-8, and HN-9 cells. Casticin (5 μM) also promotes apoptotic cell death, inhibits constitutively active STAT3 in tumor cells, modulates STAT3 activation by altering the activity of upstream STAT3 regulators, and abrogates IL-6-induced STAT3 activation. In addition, Casticin (2.5 μM) enhances the effect of ionizing radiation in 786-O cells and potentiates the therapeutic effect of radiotherapy. | ||||
| 体内研究 | Casticin (20 mg/kg, p.o.) has toxic effect on the liver in mice with CCl4-and BDL-induced hepatic injury. Casticin attenuates liver fibrosis induced by CCl4 or BDL in vivo. Casticin inhibits HSC activation and collagen matrix expression by blocking TGF-β/Smad signaling in vivo. | ||||
| 临床实验 | N/A | ||||
1. Kobayakawa J, et al. Cancer Lett. 2004,208(1):59-64.
2. Zhou L, et al. 2017,8(34):56267-56280.
3. Lee JH, et al. J Cell Biochem. 2019,120(6):9787-9798.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2163-10mM | 蔓荆子黄素(98%, HPLC) | 10mM×0.2ml |
| SM2163-5mg | 蔓荆子黄素(98%, HPLC) | 5mg |
| SM2163-25mg | 蔓荆子黄素(98%, HPLC) | 25mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
