化学信息：
| 中文名 | 羟基红花黄色素A |
| 英文名 | Safflomin A |
| 中文别名 | - |
| 英文别名 | Hydroxy safflor yellow A; HSYA |
| 来源 | 红花Carthamus tinctorius L. |
| 化合物类型 | 黄酮类(Flavonoids)>查尔酮 |
| 化学式 | C27H32O16 |
| 分子量 | 612.53 |
| CAS号 | 78281-02-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 34 mg/ml (55.51 mM); |
| Water: 33.33 mg/ml (54.41 mM) | |
| 溶液配制 | 10mg加入1.63ml DMSO，或者每6.13mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Hydroxysafflor yellow A is a flavonoid derived and isolated from traditional Chinese medicine Carthamus tinctorius L., possesses anti-tumor activity. | ||||
| 信号通路 | Rac1/Akt | ||||
| 靶点 | TNF-α | IL-6 | IL-8 | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. We further showed that HYSA inhibited LPS-induced upregulation of TLR-4 expression as well as the activation of Rac1/Akt pathway. HSYA protected EC viability against LPS-induced injury (P<0.05). LPS-induced NF-κB p65 subunit DNA binding (P<0.01) and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor -α (I-κB-α) phosphorylation was inhibited by HSYA. HSYA attenuated LPS triggered ICAM-1 and E-selectin mRNA levels elevation and phosphorylation of p38 MAPK or c-Jun N-terminal kinase MAPK. HSYA inhibited the proliferation of 3T3-L1 preadipocytes and cell viability greatly decreased in a dose and time dependent manner. HSYA (1 mg/l) notably reduced the amount of intracellular lipid and triglyceride content in adipocytes by 21.3 % (2.13 ± 0.36 vs 2.71 ± 0.40, P < 0.01) and 22.6 % (1.33 ± 0.07 vs 1.72 ± 0.07, P < 0.01) on days 8 following the differentiation, respectively. | ||||
| 体内研究 | HSYA treatment ameliorated serum biochemical indicators by reducing the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronan (HA), laminin (LN), and type III precollagen (III-C) in rats. | ||||
| 临床实验 | N/A | ||||
1. Yang G, et al. Int J Clin Exp Med. 2015,8(4):5295-302.
2. Zhu HJ, et al. Cytotechnology. 2015,67(5):885-92.
3. He Y, et al. J Physiol Biochem. 2015,71(1):69-78.
4. Jin M, et al. Chin J Integr Med. 2016,22(1):36-41.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM2009-10mM | 羟基红花黄色素A (98%, HPLC) | 10mM×0.2ml |
| SM2009-5mg | 羟基红花黄色素A (98%, HPLC) | 5mg |
| SM2009-25mg | 羟基红花黄色素A (98%, HPLC) | 25mg |
| SM2009-100mg | 羟基红花黄色素A (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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