化学信息:
中文名 | 芒果苷 |
英文名 | Mangiferin |
中文别名 | 杧果甙;芒果甙 |
英文别名 | Euxanthogen; Chinomine; Alpizarin; Hedysaride; Mannipherin; Chedisaride; Shamimin |
来源 | 红花龙胆Gentiana rhodantha Franch.;知母Anemarrhena asphodeloides Bunge |
化合物类型 | 黄酮类(Flavonoids)>(口山)酮 |
化学式 | C19H18O11 |
分子量 | 422.34 |
CAS号 | 4773-96-0 |
纯度 | 98%, HPLC |
溶剂/溶解度 | DMSO: 22 mg/ml (52.09 mM; Need ultrasonic and warming) |
溶液配制 | 5mg加入1.18ml DMSO,或者每4.22mg加入1ml DMSO,配制成10mM溶液。 |
生物信息
产品描述 | Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50. | ||||
信号通路 | - | ||||
靶点 | p65 | p50 | Nrf2 | - | - |
IC50 | - | - | - | - | - |
体外研究 | Mangiferin is glucosylxanthone extracted from plants of the Anacardiaceae and Gentianaceae families. Mangiferin (50 μM) significantly increases Nrf2 protein accumulation in HL-60 cells, particularly in the nucleus. Mangiferin also enhances the binding of Nrf2 to an antioxidant response element (ARE), significantly up-regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) expression and reduces intracellular ROS in HL60 cells. Mangiferin alone dose-dependently inhibits the proliferation of HL-60 cells. In mononuclear cells (MNCs), Mangiferin significantly relieves oxidative stress, but attenuates etoposide-induced cytotoxicity. Mangiferin is a natural phytopolyphenol that exhibits various pharmacological properties. Mangiferin is present in several plant species such as Mangifera indica, Iris unguicularis, and Anemarrhena asphodeloides. Mangiferin downregulates TNF-α-induced MMP-9 mRNA and protein expression by suppressing NF-κB activity, consequently suppressing the invasion of LNCaP cells.To assess whether Mangiferin influences the viability of LNCaP cells, MTT assay is performed 24 h after treatment with different concentrations of Mangiferin in the presence or absence of TNF-α in serum and serum-free conditions. There are no cytotoxic evident in LNCaP cells treated with up to 400 μM of Mangiferin alone under both serum and serum-free conditions. Additionally, in the presence of TNF-α (20 ng/ml), Mangiferin does not affect cell viability. Mangiferin (400 μM) treatment significantly decreases the NF-κB luciferase activity in TNF-α-stimulated LNCaP cells. Pretreatment with Mangiferin (400 μM) for 1 h significantly decreases TNF-α-induced NF-κB activity. The RT-PCR shows that Mangiferin (400 μM) significantly suppresses the TNF-α-induced MMP-9 expression in LNCaP cells. | ||||
体内研究 | N/A | ||||
临床实验 | N/A |
1. Zhang BP, et al. Acta Pharmacol Sin. 2014,35(2):257-66.
2. Dilshara MG, et al. BMB Rep. 2015,48(10):559-64.
包装清单:产品编号 | 产品名称 | 包装 |
SM2001-10mM | 芒果苷(98%, HPLC) | 10mM×0.2ml |
SM2001-5mg | 芒果苷(98%, HPLC) | 5mg |
SM2001-25mg | 芒果苷(98%, HPLC) | 25mg |
SM2001-100mg | 芒果苷(98%, HPLC) | 100mg |
- | 说明书 | 1份 |
-20℃保存,至少一年有效。固体粉末4℃保存,至少一个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。
注意事项:本产品可能对人体有一定的毒害作用,请注意适当防护,以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
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