| 中文名 | 姜黄素 |
| 英文名 | Curcumin |
| 中文别名 | 酸性黄；姜黄色素 |
| 英文别名 | Diferuloylmethane |
| 来源 | 姜黄Curcuma longa L. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>木脂素>简单木脂素 |
| 化学式 | C21H20O6 |
| 分子量 | 368.38 |
| CAS号 | 458-37-7 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
DMSO: 120 mg/mL (325.75 mM) Water: < 0.1 mg/mL (insoluble) |
| 溶液配制 | 5mg加入1.36ml DMSO，或者每3.68mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. | ||||
| 信号通路 | NF-κB; MAPK | ||||
| 靶点 | p300/CREB-binding protein | Keap1-Nrf2 | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Curcumin exerts its chemopreventive effects partly through the activation of nuclear factor (erythroid-2 related) factor 2 (Nrf2) and its antioxidant and phase II detoxifying enzymes. Curcumin inhibits T47D cells growth, with IC50s of 25, 19 and 17.5 μM for 24, 48 and 72 h MTT assays respectively. IC50s of curcumin and silibinin mixture against T47D cells, are 17.5, 15, and 12 μM for 24, 48, and 72 h exposure times, respectively. Curcumin (2.5-80 μM) induces apoptotic cell death in AGS and HT-29 cell lines, and the IC50 is 21.9±0.1, 40.7±0.5 μM, respectively, in both AGS and HT-29 cell lines. Curcumin-induced apoptosis requires caspase activities in AGS and HT-29 cells. Curcumin induces ER Ca2+ decline and mitochondrial Ca2+ overloading. Curcumin induces the G2/M cell cycle arrest of LNCaP and PC-3 cells in a dose dependent manner. Curcumin upregulates the protein level of NF-kappaB inhibitor IkappaBalpha and downregulates protein levels of c-Jun and AR. | ||||
| 体内研究 | Curcumin (10 mg/kg, p.o.) significantly prevents decrease in the percentage of sucrose consumption, as compared to the CMS-exposed rats. Curcumin treatment results in significant prevention of increase in TNF-α and IL-6 levels in stressed rats. Curcumin decreases binding of p300/CREB-binding protein (CBP) at the brain-derived neurotrophic factor (BDNF) promoter at 20 mg/kg (i.p.), reduces binding of P300/CBP at the BDNF promoter at 40 mg/kg, and decreases binding all the four proteins of p300/CBP and H3K9ac/H4K5ac at the BDNF promoter at 60 mg/kg in chronic constriction injury (CCI) rats. | ||||
| 临床实验 | NCT04528212: Diabetes Mellitus, Type 2, Phase 4; NCT04044417: Periodontitis, Phase 4; NCT02532023: Migraine, Phase 4; NCT01052597: Type 2 Diabetes Mellitus|Cardiovascular Abnormalities, Phase 4; NCT03917784: PreDiabetes, Phase 4; NCT04205929: Bleeding|Implants|Breakthrough Bleeding, Phase 4; NCT00779493: Irritable Bowel Syndrome, Phase 4; NCT02494141: Polycystic Kidney, Autosomal Dominant, Phase 4; NCT01750359: Major Depression, Phase 4; NCT04032132: Periodontitis, Phase 4; NCT02298985: Chronic Schizophrenia, Phase 4; NCT01052025: Type 2 Diabetes|Pre-diabetes|Insulin Resistance|Cardiovascular Risk, Phase 4. | ||||
1.Gao S, et al. Food Chem Toxicol. 2013,59:739-47.
2.Nasiri M, et al. Asian Pac J Cancer Prev. 2013,14(6):3449-53.
3.Cao A, et all. Apoptosis. 2013,18(11):1391-1402.
4.Jiang H, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2013,47:33-9.
5.Guo H, et al. Pharmazie. 2013,68(6):431-4.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1079-10mM | 姜黄素(98%, HPLC) | 10mM×0.2ml |
| SM1079-25mg | 姜黄素(98%, HPLC) | 25mg |
| SM1079-100mg | 姜黄素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
