| 中文名 | 丁香酚 |
| 英文名 | Eugenol |
| 中文别名 | 丁香油酚；丁子香酚；丁子香酸；烯丙基甲氧基苯酚；异丁香酚苯乙醚 |
| 英文别名 | 4-Allyl-2-methoxyphenol; 5-Allylguaiacol |
| 来源 | 丁香Eugenia caryophyllata Thunb.；肉豆蔻Myristica fragrans Houtt. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)＞苯丙烯类 |
| 化学式 | C10H12O2 |
| 分子量 | 164.21 |
| CAS号 | 97-53-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/ml (609.01 mM) |
| 溶液配制 | 2mg加入1.22ml DMSO，或者每1.64mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation. | ||||
| 信号通路 | - | ||||
| 靶点 | Bacterial | Parasite | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | The essential oil of O. gratissimum, as well as eugenol, are efficient in inhibiting eclodibility of H. contortus eggs, showing possible utilizations in the treatment of gastrointestinal helmintosis of small ruminants. At 0.50% concentration, the essential oil and eugenol show a maximum eclodibility inhibition. Eugenol inhibits superoxide anion generation in xanthine-xanthine oxidase system to an extent of 50% at concentrations of 250 μM. Eugenol also inhibits the generation of hydroxyl radicals to an extent of 70%. The OH-radical formation measured by the hydroxylation of salicylate to 2, 3-dihydroxy benzoate is inhibited to an extent of 46% by eugenol at 250 μM. Eugenol protects against RS-induced development of IBS-like gastrointestinal dysfunction through modulation of HPA-axis and brain monoaminergic pathways apart from its antioxidant effect. Eugenol (50 mg/kg) reduces 80% of RS-induced increase in fecal pellets similar to that of ondansetron. Eugenol attenuates 80% of stress-induced increase in plasma corticosterone and modulates the serotonergic system in the PFC and amygdala. Eugenol attenuates stress-induced changes in norepinephrine and potentiates the antioxidant defense system in all brain regions. | ||||
| 体内研究 | Eugenol (33 mg/kg) administered orally for 2 days causes significant suppression of knee joint edema, which continues to be significantly reduced at the end of the treatment. After 2 days, eugenol-treated mycobacterial arthritic rats show a marked reduction in paw swelling. | ||||
| 临床实验 | NCT03437655: MTA|Dental Restoration, Temporary, Not Applicable. | ||||
1.Pessoa LM, et al. 2002,109(1-2):59-63.
2.Reddy AC, et al. Mol Cell Biochem. 1994,137(1):1-8.
3.Garabadu D, et al. Pharm Biol. 2015,53(7):968-74.
4.Sharma JN, et al. 1994,49(5):314-8.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1060-25mg | 丁香酚(98%, HPLC) | 25mg |
| SM1060-100mg | 丁香酚(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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