化学信息：
| 中文名 | 连翘酯苷B |
| 英文名 | Forsythoside B |
| 中文别名 | 连翘脂苷 B；连翘酯甙 B |
| 英文别名 | - |
| 来源 | 连翘Forsythia suspensa (Thunb.) Vahl |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>苯丙酸类 |
| 化学式 | C34H44O19 |
| 分子量 | 756.7 |
| CAS号 | 81525-13-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 125 mg/ml (165.19 mM); Water: 110 mg/ml (145.37 mM) |
| 溶液配制 | 10mg加入1.32ml DMSO，或者每7.57mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Forsythoside B is a phenylethanoid glycoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB. | ||||
| 信号通路 | IKK | ||||
| 靶点 | TNF-α | IL-6 | HMGB1 | NF-κB | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Forsythoside B concentration-dependently down-regulates the levels of TNF-α, IL-6 and high-mobility group-box 1 protein (HMGB1) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, inhibits the IκB kinase (IKK) pathway and modulated nuclear factor (NF)- κB. | ||||
| 体内研究 | Intravenous injection of forsythoside B alone or plus imipenem reduces serum levels of TNF-α, IL-6, HMGB1, triggering receptor expressed on myeloid cells (TREM-1) and endotoxin, while the serum level of IL-10 is up-regulated and myeloperoxidase (MPO) in lung, liver and small intestine is reduced. Forsythoside B at doses higher than 8 mg/kg produces a significant neuroprotective potential in cerebral ischemia and reperfusion rats. Forsythoside B (20 mg/kg) demonstrates significant neuroprotective activity even after delayed administration at 1 h, 3 h and 5 h after cerebral ischemia and reperfusion. Forsythoside B 20 mg/kg attenuates histopathological damage as demonstrated by smaller brain infarct size and brain edema, decreased cerebral Evans blue extravasation and myeloperoxidase activity, inhibited cerebral phosphor-IκB-α and NF-κB expression. Forsythoside B shows a significant recovery in myocardial function with improvement of LVSP and +/-dp/dt(max). The myocardial infarct volume, serum levels of Tn-T, TNF-alpha and IL-6, content of MDA and MPO activity in myocardial tissue are all reduced, protein expression of HMGB1, phosphor-I kappaB-alpha and phosphor-NF-kappaB are down-regulated, while attenuate the decrease of SOD and GPx activities. | ||||
| 临床实验 | N/A | ||||
1. Jiang WL, et al. Phytother Res. 2012,26(7):981-7.
2. Jiang WL, et al. Eur J Pharmacol. 2010,640(1-3):75-81.
3. Jiang WL, et al. Phytomedicine. 2010,17(8-9):635-9.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1035-10mM | 连翘酯苷B (98%, HPLC) | 10mM×0.2ml |
| SM1035-5mg | 连翘酯苷B (98%, HPLC) | 5mg |
| SM1035-25mg | 连翘酯苷B (98%, HPLC) | 25mg |
| SM1035-100mg | 连翘酯苷B (98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
