丹酚酸B (98%, HPLC)
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产品编号 SM1015-25mg
数量
¥ 1080.00
产品包装:
5mg 25mg 100mg
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化学信息:

中文名 丹酚酸B
英文名 Salvianolic acid B
中文别名 丹参酚酸B;丹酚酸乙;紫草酸B
英文别名 Lithospermic acid B;Danshensuan B
来源 丹参Salvia miltiorrhiza Bunge
化合物类型 苯丙素类(Phenylpropanoids)>苯丙酸类
化学式 C36H30O16
分子量 718.61
CAS号 121521-90-2
纯度 98%, HPLC
溶剂/溶解度 Water : 50 mg/ml (69.58 mM; adjust pH to 3 with HCl); DMSO: 25 mg/ml (34.79 mM)
溶液配制 10mg加入1.39ml DMSO,或者每7.19mg加入1ml DMSO,配制成10mM溶液。

生物信息

产品描述 Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
信号通路 Inflammatory
靶点 MAPK - - - -
IC50 1 μM - - - -
体外研究 Salvianolic acid B (SA-B) 1 and 10 micromol/L decrease the cell active TGF-beta1 secretion by 63.3 % and 15.6 % of the control, down-regulat pro-collgen alpha1(I) mRNA expression to 77.0% and 51.8% respectively (P<0.05). SA-B 1 and 10 micromol/L also inhibit MAPK activity by 1 to 2 fold respectively. The degradation of Salvianolic acid B is temperature dependent. It was stable at 4ºC for 30 h in aqueous solution. However, decomposition of Salvianolic acid B aqueous solution occurres automatically at 25ºC, and is enhanced at 37, 65 and 100ºC. On the other hand, Salvianolic acid B is also stable at 4, 25 and 37ºC for 30 h in TPA (total phenolic acids). Salvianolic acid B is stable for 30 h in buffered phosphate aqueous solutions at pH 1.5, 3.0 and 5.0. With an increase of pH from the neutral, the stability of Sal B decreased.
体内研究 Salvianolic acid B (SalB) (5 mg · kg-1 · h-1) significantly attenuates LPS-induced pulmonary microcirculatory disturbance, including the increase in leukocyte adhesion and albumin leakage. In addition, LPS increases pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor [alpha] and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhances the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, whereas it decreases the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which are attenuated by SalB pretreatment1. SalB administration (10 mg/kg) significantly ameliorate the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that are observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduce inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which are increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescue the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels.
临床实验 N/A
参考文献:

1. Lee YW, et al. Eur J Pharmacol. 201,704(15):70-7.

2. Liu P, et al. Acta Pharmacol Sin. 2002,23(8):733-8.

3. Lin, Fang, et al. Shock. 2013,39(3):317-25.

4. Man Xu, et al. Natural Product Communications. 2008,3(5):669-676.

包装清单:
产品编号 产品名称 包装
SM1015-5mg 丹酚酸B (98%, HPLC) 5mg
SM1015-25mg 丹酚酸B (98%, HPLC) 25mg
SM1015-100mg 丹酚酸B (98%, HPLC) 100mg
- 说明书 1份
保存条件:

-20℃保存,至少一年有效。固体粉末4℃保存,至少一个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。

注意事项:

本产品可能对人体有一定的毒害作用,请注意适当防护,以避免直接接触人体或吸入体内。

本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。

为了您的安全和健康,请穿实验服并戴一次性手套操作。

使用说明:
1. 收到产品后请立即按照说明书推荐的条件保存。使用前可以在2,000-10,000g离心数秒,使粉末充分沉降至管底后再开盖使用。
2. 该产品在溶液中不稳定,建议现用现配。具体的最佳工作浓度请参考本说明书中的体外、体内研究结果或其它相关文献,或者根据实验目的,以及所培养的特定细胞和组织,通过实验进行摸索和优化。
3. 不同实验动物依据体表面积的等效剂量转换表请参考如下网页:
https://www.beyotime.com/support/animal-dose.htm
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