化学信息：
| 化学名 | ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate |
|
| 简称 | ITD 1 | |
| 别名 |
ITD-1, ITD1, SCHEMBL3239096, AOB6123 |
|
| 中文名 | N/A | |
| 化学式 | C27H29NO3 | |
| 分子量 | 415.52 | |
| CAS号 | 1099644-42-4 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO9mg/ml; Ethanol<1mg/ml |
|
| 溶液配制 | 5mg加入1.2ml DMSO，或者每4.16mg加入1ml DMSO，配制成10mM溶液。SF7899-10mM用DMSO配制。 |
生物信息：
| 产品描述 | ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50=0.85μM). | ||||
| 信号通路 | TGF-beta/Smad | ||||
| 靶点 | TGFβ | － | － | － | － |
| IC50 | 0.85μM | － | － | － | － |
| 体外研究 | ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 is the first selective TGFβ inhibitor and reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors. ITD-1 downregulates HA-TGFBR2 and TGFBR2-mCherry with nearly the same potency (IC50=1.05 and 1.31μM, respectively). ITD-1 acts by enhancing degradation rather than by blocking synthesis, which would affect cell surface and intracellular receptor pools equally. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SF7899-10mM | ITD 1 (TGF-β Receptor抑制剂) | 10mM×0.2ml |
| SF7899-5mg | ITD 1 (TGF-β Receptor抑制剂) | 5mg |
| SF7899-25mg | ITD 1 (TGF-β Receptor抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
