化学信息：
| 化学名 | (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide |
|
| 简称 | Marimastat | |
| 别名 |
BB2516, TA2516, BB-2516 |
|
| 中文名 | 马立马司他 | |
| 化学式 | C15H29N3O5 | |
| 分子量 | 331.41 | |
| CAS号 | 154039-60-8 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO40mg/ml; Ethanol<1mg/ml |
|
| 溶液配制 | 5mg加入1.51ml DMSO，或者每3.31mg加入1ml DMSO，配制成10mM溶液。SD7176-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Marimastat (BB 2516; TA2516) is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). | ||||
| 信号通路 | Metabolism; Proteases | ||||
| 靶点 | MMP-9 | MMP-1 | MMP-2 | MMP-14 | MMP-7 |
| IC50 | 3nM | 5nM | 6nM | 9nM | 13nM |
| 体外研究 | Marimastat early downregulated the expression of Notch target genes, such as Hes1 and Hes5. MMP-2 and MMP-9 profiling on proliferating and differentiating NPs. | ||||
| 体内研究 | The marimastat was administered at a dose of 8.7mg/kg/day over a 14-day period via a subcutaneous osmotic pump. The control group received vehicle only via a subcutaneous osmotic pump.Chemoradiation + marimastat therapy had delayed tumor growth, compared to the chemoradiation alone. | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SD7176-10mM | Marimastat (MMP抑制剂) | 10mM×0.2ml |
| SD7176-5mg | Marimastat (MMP抑制剂) | 5mg |
| SD7176-25mg | Marimastat (MMP抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
