化学信息：
| 化学名 | 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione |
|
| 简称 | PSI-6206 | |
| 别名 |
RO 2433, PSI 6206, PSI6206, RO2433, RO-2433 |
|
| 中文名 | N/A | |
| 化学式 | C10H13FN2O5 | |
| 分子量 | 260.22 | |
| CAS号 | 863329-66-2 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO3mg/ml; Ethanol<1mg/ml |
|
| 溶液配制 | 5mg加入1.92ml DMSO，或者每2.6mg加入1ml DMSO，配制成10mM溶液。SC3314-10mM用DMSO配制。 |
生物信息：
| 产品描述 | PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor. | ||||
| 信号通路 | Anti-infection | ||||
| 靶点 | HCV | － | － | － | － |
| IC50 | － | － | － | － | － |
| 体外研究 | PSI-6206 is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. The monophosphate form of PSI-6206 was shown to be metabolized in primary human hepatocytes to its triphosphate analog PSI-7409. Furthermore, the phosphoramidate prodrug of PSI-6206 monophosphate, PSI-7851, was developed. Alternatively, PSI-6130, an aminated analog of PSI-6206 monophosphate, was also developed. PSI-7409, the triphosphate of PSI-6206 inhibits wild-type and S282T HCV RdRp with Ki values of 0.42 and 22μM, respectively. PSI-7851, the phosphoramidate of PSI-6206 monophosphate, showed an EC50 value of 1.62μM for inhibiting HCV RNA replication. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SC3314-10mM | PSI-6206 (HCV抑制剂) | 10mM×0.2ml |
| SC3314-5mg | PSI-6206 (HCV抑制剂) | 5mg |
| SC3314-25mg | PSI-6206 (HCV抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
