化学信息：
| 化学名 | 1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea |
|
| 简称 | LED209 | |
| 别名 |
LED 209, LED-209 |
|
| 中文名 | N/A | |
| 化学式 | C19H17N3O2S2 | |
| 分子量 | 383.49 | |
| CAS号 | 245342-14-7 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO20mg/ml; Ethanol20mg/ml |
|
| 溶液配制 | 5mg加入1.3ml DMSO，或者每3.83mg加入1ml DMSO，配制成10mM溶液。SC3310-10mM用DMSO配制。 |
生物信息：
| 产品描述 | LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC. | ||||
| 信号通路 | Anti-infection | ||||
| 靶点 | Antibacterial | － | － | － | － |
| IC50 | － | － | － | － | － |
| 体外研究 | LED209 has desirable pharmacokinetics and does not present toxicity in vitro and in rodents. This is a unique antivirulence approach, with a proven broad-spectrum activity against multiple Gram-negative pathogens that cause mammalian infections.The LED209 QseC inhibitor has a unique mode of action by acting as a prodrug scaffold to deliver a warhead that allosterically modifies QseC, impeding virulence in several Gram-negative pathogens. LED209 is QseC sensor kinase inhibitor , as a potential lead compound to combat infections with Legionella or Mycobacterium spp. LED209 inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 inhibits EHEC virulence traits in vitro. LED209 markedly inhibits the virulence of several pathogens in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SC3310-10mM | LED209 (QseC抑制剂) | 10mM×0.2ml |
| SC3310-5mg | LED209 (QseC抑制剂) | 5mg |
| SC3310-25mg | LED209 (QseC抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
