化学信息：
| 化学名 | 3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one |
|
| 简称 | Tedizolid | |
| 别名 |
TR-700, DA-7157, Torezolid, TR 700, DA 7157 |
|
| 中文名 | 特地唑胺 | |
| 化学式 | C17H15FN6O3 | |
| 分子量 | 370.34 | |
| CAS号 | 856866-72-3 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO4mg/ml; Ethanol<1mg/ml |
|
| 溶液配制 | 5mg加入1.35ml DMSO，或者每3.7mg加入1ml DMSO，配制成10mM溶液。SC3265-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Torezolid (TR-701; tedizolid) is a novel oxazolidinone for gram-positive infections. | ||||
| 信号通路 | Anti-infection | ||||
| 靶点 | MAO-A | MAO-B | － | － | － |
| IC50 | 8.7μM | 5.7μM | － | － | － |
| 体外研究 | Tedizolid was reversible inhibitors of human MAO-A and MAO-B; the 50% inhibitory concentration (IC50) for tedizolid was 8.7μM for MAO-A and 5.7μM for MAO-B. Tedizolid phosphate was negative in the mouse head twitch model of serotonergic activity. Two randomized placebo-controlled crossover clinical studies assessed the potential of 200mg/day tedizolid phosphate (at steady state) to enhance pressor responses to coadministered oral tyramine or pseudoephedrine. Sensitivity to tyramine was determined by comparing the concentration of tyramine required to elicit a ≥30mmHg increase in systolic blood pressure (TYR30) when administered with placebo versus tedizolid phosphate. The geometric mean tyramine sensitivity ratio (placebo TYR30/tedizolid phosphate TYR30) was 1.33; a ratio of ≥2 is considered clinically relevant. In the pseudoephedrine study, mean maximum systolic blood pressure was not significantly different when pseudoephedrine was coadministered with tedizolid phosphate versus placebo. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SC3265-10mM | Tedizolid (MAO-A抑制剂) | 10mM×0.2ml |
| SC3265-5mg | Tedizolid (MAO-A抑制剂) | 5mg |
| SC3265-25mg | Tedizolid (MAO-A抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
