化学信息：
| 化学名 | (2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid |
|
| 简称 | MMAF | |
| 别名 |
Monomethylauristatin F |
|
| 中文名 | 一甲基澳瑞他汀 | |
| 化学式 | C39H65N5O8 | |
| 分子量 | 731.96 | |
| CAS号 | 745017-94-1 | |
| 纯度 | 98% | |
| 溶剂/溶解度 |
Water<1mg/ml; DMSO10mg/ml; Ethanol<1mg/ml |
|
| 溶液配制 | 5mg加入0.68ml DMSO，或者每7.32mg加入1ml DMSO，配制成10mM溶液。SC2243-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; antibody drug cytotoxin. | ||||
| 信号通路 | Antibody-drug conjugates; Cell Cycle; DNA Damage | ||||
| 靶点 | Tubulin | ADCs cytotoxin | － | － | － |
| IC50 | － | － | － | － | － |
| 体外研究 | MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because ofmMAF is highly toxic, it cannot be used as a drug itself. mMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SC2243-10mM | MMAF (Tubulin抑制剂) | 10mM×0.2ml |
| SC2243-5mg | MMAF (Tubulin抑制剂) | 5mg |
| SC2243-25mg | MMAF (Tubulin抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
