U0126 (MEK1/2抑制剂)
收藏
：
产品编号 ： S1901-5mg
数量 ：
¥ 679.00 元
产品包装:
10mg/ml×0.1ml 5mg 25mg 100mg
产品简介
使用说明
相关文件下载
相关产品
相关论文
产品问答

U0126即1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene，是一种常用的MAPKK抑制剂，即MAPK kinase抑制剂或MEK1/2抑制剂。U0126可以通透细胞，选择性抑制MEK1/2，从而抑制MAP kinase (Erk1/2即p44/42 MAPK)的磷酸化和激活。同时可以抑制AP-1依赖的基因转录激活。
U0126分子量为380.50，分子式为C18H16N6S2，CAS Number：109511-58-2。本产品纯度大于98%。
本U0126为进口分装，其中10mg/ml包装用DMSO配制，共0.1ml。5mg，25mg和100mg为粉末装。
包装清单：

产品编号 产品名称 包装
S1901-1mg U0126 (MEK1/2抑制剂) 10mg/ml×0.1ml
S1901-5mg U0126 (MEK1/2抑制剂) 5mg
S1901-25mg U0126 (MEK1/2抑制剂) 25mg
S1901-100mg U0126 (MEK1/2抑制剂) 100mg
— 说明书 1份

保存条件：
-20℃避光保存，一年有效。
注意事项：
本产品对人体有害，操作时请小心，并注意有效防护以避免直接接触人体或吸入体内。
本U0126在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. U0126常见使用浓度范围为1-20μM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

相关产品请点击如下按钮：
使用本产品的文献：
1. Shen J, Jiang F, Yang Y, Huang G, Pu F, Liu Q, Chen L, Ju L, Lu M, Zhou F, Zhang C, Luo X, Yang X, Jiao C, Li X, Li Z, Li Y, Zhang J.
J Hepatol 2016 Nov;65(5):953-962. (IF 20.582)
2. You M, Dong G, Li F, Ma F, Ren J, Xu Y, Yue H, Tang R, Ren D, Hou Y.
Cell Mol Immunol 2013 Feb;27(2):251-7. (IF 8.484)
3. Li Y, Wu Z, Yuan J, Sun L, Lin L, Huang N, Bin J, Liao Y, Liao W.
Cancer Lett 2017 Jun 1;395:31-44. (IF 7.36)
4. Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G.
Sci Signal 2012 Aug 21;5(238):ra61. (IF 6.467)
5. Zhang Z, Miao L, Lv C, Sun H, Wei S, Wang B, Huang C, Jiao B.
Cell Death Dis 2013 Jun 6;4:e657. (IF 6.304)
6. Shen M, Liu Z, Li B, Teng Y, Zhang J, Tang Y, Sun SC, Liu H.
Cell Death Dis 2014 Oct 16;5:e1475. (IF 6.304)
7. Xia Q, Hu Q, Wang H, Yang H, Gao F, Ren H, Chen D, Fu C, Zheng L, Zhen X, Ying Z, Wang G.
Cell Death Dis 2015 Mar 26;6:e1702. (IF 6.304)
8. Han Y, Wu Z, Wu T, Huang Y, Cheng Z, Li X, Sun T, Xie X, Zhou Y, Du Z.
Cell Death Dis 2016 Mar 3;7:e2123. (IF 6.304)
10. Zhou M, Fu J, Xiao L, Yang S, Song Y, Zhang X, Feng X, Sun H, Xu W, Huang W.
Hum Reprod 2016 Nov;31(11):2598-2608. (IF 5.733)
12. Qi R, Liu H, Wang Q, Wang J, Yang F, Long D, Huang J.
CELL PHYSIOL BIOCHEM 2017;44(6):2467-2475. (IF 5.5)
13. Yang M, Wang X, Wang L, Wang X, Li J, Yang Z.
CELL PHYSIOL BIOCHEM 2017;41(1):265-273. (IF 5.5)
14. Gao M, Kong Q, Hua H, Yin Y, Wang J, Luo T, Jiang Y.
ONCOTARGET 2016 Mar 29;7(13):16349-61. (IF 5.168)
15. Wu D, Cheng J, Sun G, Wu S, Li M, Gao Z, Zhai S, Li P, Su D, Wang X.
ONCOTARGET 2016 Jun 14;7(24):36539-36550. (IF 5.168)
16. Yu D, Geng H, Liu Z, Zhao L, Liang Z, Zhang Z, Xie D, Wang Y, Zhang T, Min J, Zhong C.
ONCOTARGET 2017 Jan 31;8(5):8791-8800. (IF 5.168)
17. Zhao K, Zhang S, Song X, Yao Y, Zhou Y, You Q, Guo Q, Lu N.
ONCOTARGET 2017 Apr 18;8(16):27120-27136. (IF 5.168)
18. Lin Y, Cong H, Liu K, Jiao Y, Yuan Y, Tang G, Chen Y, Zheng Y, Xiao J, Li C, Chen Z, Cao P
Front Immunol. 10:1132. (IF 5.085)
19. Fan B, Wang BF, Che L, Sun YJ, Liu SY, Li GY.
Oxid Med Cell Longev 2017;2017:5093473. (IF 5.076)
20. Li T, Xu XH, Tang ZH, Wang YF, Leung CH, Ma DL, Chen XP, Wang YT, Chen Y, Lu JJ.
Acta Pharmacol Sin 2015 Dec;36(12):1503-13. (IF 5.064)
21. Liang X, So YH, Cui J, Ma K, Xu X, Zhao Y, Cai L, Li W.
J Radiat Res 2011;52(3):380-6. (IF 1.95)
22. Fang S, Jin Y, Zheng H, Yan J, Cui Y, Bi H, Jia H, Zhang H, Wang Y, Na L, Gao X, Zhou H.
Mol Cell Biochem 2011 Jan;347(1-2):175-82. (IF 2.795)
23. Pu J, Peng G, Li L, Na H, Liu Y, Liu P.
J Lipid Res 2011 Jul;52(7):1319-27. (IF 4.483)
24. Xie H, Hua C, Sun L, Zhao X, Fan H, Dou H, Sun L, Hou Y.
ARTHRITIS RHEUM-US  2011 Aug;63(8):2425-35.
25. Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y, Nie X, Liu M, Ran Y, Zhu D.
J Lipid Res 2012 Jun;53(6):1093-105. (IF 4.483)
26. Zhu F, Shen F, Fan Y, Xie Y, Xia Y, Kong Y.
GLYCOCONJUGATE J 2012 Aug;29(5-6):347-56. (IF 2.197)
27. Zhao X, Liu L, Liu D, Fan H, Wang Y, Hu Y, Hou Y.
Am J Reprod Immunol 2012 Oct;68(4):290-300. (IF 2.739)
28. Zhou F, Chen S, Xiong J, Li Y, Qu L.
Biol Trace Elem Res 2012 Nov;149(2):273-9. (IF 2.639)
29. Zhang X, Ding R, Zhou Y, Zhu R, Liu W, Jin L, Yao W, Gao X.
PLoS One 2013;8(3):e60781. (IF 2.74)
30. Ye L, Shi Z, Liu H, Yang X, Wang K.
Biol Trace Elem Res 2013 Jan;151(1):148-55. (IF 2.639)
31. Xue P, Wu X, Zhou L, Ma H, Wang Y, Liu Y, Ma J, Li Y.
BIOCHEM BIOPH RES CO 2013 Apr 5;433(2):226-31. (IF 2.985)
32. Li HJ, Guo LM, Yang LL, Zhou YC, Zhang YJ, Guo J, Xie XJ, Guo GZ.
Toxicol Lett 2013 Jun 20;220(1):35-43. (IF 3.569)
33. Wang S, Zhao Z, Bi Y, Sun L, Liu X, Liu W.
J Virol 2013 Jun;87(11):6182-91. (IF 4.501)
34. Liu P, Wang YY, Qi X, Gu Q, Geng M, Li J.
PLoS One 2013 Jun 14;8(6):e65381. (IF 2.74)
36. Liu T, Yi W, Feng B, Zhou Z, Xiao G.
PLoS One 2013 Aug 14;8(8):e71896. (IF 2.74)
37. Zhou R, Yao X, Xu X, Wang G, Zhu Z, Chen J, Chen L, Shen X.
Steroids 2013 Oct;78(10):987-95. (IF 1.948)
38. Shen Y, Zhao Y, Zheng D, Chang X, Ju S, Guo L.
J STEROID BIOCHEM 2013 Nov;138:376-83. (IF 3.813)
39. Lin B, Xu Y, Zhang B, He Y, Yan Y, He MC.
Exp Ther Med 2014 Jan;7(1):66-72. (IF 1.785)
40. Wang Y, Liu D, Zhao H, Jiang H, Luo C, Wang M, Yin H.
Mol Cell Endocrinol 2014 Feb 15;382(2):979-88. (IF 3.871)
41. Lv S1, Yi PF, Shen HQ, Zhang LY, Dong HB, Wu SC, Xia F, Guo X, Wei XB, Fu BD.
IMMUNOPHARM IMMUNOT 2014 Feb;36(1):43-51. (IF 2.352)
42. Jiao S, Wu M, Ye F, Tang H, Xie X, Xie X.
PLoS One 2014 Mar 17;9(3):e92172. (IF 2.74)
44. Song MY, Yu JZ, Zhao DM, Wei S, Liu Y, Hu YM, Zhao WC, Yang Y, Wu H.
Cell Biochem Biophys 2014 May;69(1):47-54. (IF 2.073)
45. Liu Y, Mei C, Liu H, Wang H, Zeng G, Lin J, Xu M.
BIOCHEM BIOPH RES CO 2014 Sep 5;451(4):592-8. (IF 2.985)
46. Liu P, Kong F, Wang J, Lu Q, Xu H, Qi T, Meng J.
Exp Cell Res 2015 Feb 1;331(1):82-96. (IF 3.383)
47. Li T, Tang ZH, Xu WS, Wu GS, Wang YF, Chang LL, Zhu H, Chen XP, Wang YT, Chen Y, Lu JJ.
Eur J Pharmacol 2015 Feb 15;749:81-8. (IF 3.263)
48. Yuan H, Chen R, Wu L, Chen Q, Hu A, Zhang T, Wang Z, Zhu X.
Mol Neurobiol 2015 Apr;51(2):512-22. (IF 4.5)
49. Wang Y, Zhao S, Wu Z, Feng Y, Zhao C, Zhang C.
CLIN EXP PHARMACOL P  2015 May;42(5):465-74. (IF 2.092)
50. Chen Y, Yan H, Song Z, Chen F, Wang H, Niu J, Shi X, Zhang D, Zhang N, Zhai Z, Zhong B, Cheng L, Qian T, Hao F.
PLoS One 2015 Jun 5;10(6):e0127957. (IF 2.74)
51. Shang L, Jia SS, Jiang HM, Wang H, Xu WH, Lv CJ.
TUMOR BIOL  2015 Jun;36(6):4819-24. (IF 3.65)
55. Li M, Li S, Li Y.
Cell Mol Neurobiol 2015 Oct;35(7):987-93. (IF 3.606)
56. Gu YY, Yang M, Zhao M, Luo Q, Yang L, Peng H, Wang J, Huang SK, Zheng ZX, Yuan XH, Liu P, Huang CZ.
TUMOR BIOL  2015 Nov;36(11):8379-87. (IF 3.65)
57. Fan X, Xiong H, Wei J, Gao X, Feng Y, Liu X, Zhang G, He QY, Xu J, Liu L.
SCI REP-UK 2015 Dec 7;5:17732. (IF 3.998)
58. Li W, Li G, Zhang Y, Wei S, Song M, Wang W, Yuan X, Wu H, Yang Y.
Exp Cell Res 2015 Dec 10;339(2):367-79. (IF 3.383)
59. Wen J, Zhao Y, Guo L.
Int J Mol Med 2016 Jan;37(1):126-32. (IF 3.098)
61. Yu M, Chen R, Jia Z, Chen J, Lou J, Tang S, Zhang X.
Int J Toxicol 2016 Jan-Feb;35(1):17-26. (IF 1.255)
62. Hu A, Yuan H, Wu L, Chen R, Chen Q, Zhang T, Wang Z, Liu P, Zhu X.
Brain Res 2016 Jan;1631(15):204-13. (IF 2.733)
64. Yu M, Chen R, Jia Z, Chen J, Lou J, Tang S, Zhang X.
Int J Toxicol 2016 Jan-Feb;35(1):17-26. (IF 1.255)
66. Li Z, Wang S, Zhao W, Sun Z, Yan H, Zhu J.
Mol Med Rep 2016 Feb;13(2):1709-16. (IF 2.1)
68. Chen Q, Zhu L, Zheng B, Wang J, Song X, Zheng W, Wang L, Yang D, Wang J.
Int J Mol Sci 2016 May 14;17(5). pii: E738. (IF 4.556)
69. Wang Y, Cao J, Fan Y, Xie Y, Xu Z, Yin Z, Gao L, Wang C.
Int J Mol Med 2016 Jun;37(6):1567-75. (IF 3.098)
70. Wu W, Sun Y, Zhao C, Zhao C, Chen X, Wang G, Pang W, Yang G.
ACTA BIOCH BIOPH SIN 2016 Jun;48(6):509-19. (IF 2.836)
71. Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su H, Li P, Wan JB, He C.
SCI REP-UK 2016 Jun 6;6:26064. (IF 3.998)
72. Li P, Xu Y, Gan Y, Song L, Zhang C, Wang L, Zhou Q.
Int J Med Sci 2016 Jul 18;13(8):629-37. (IF 2.523)
73. Wang J, Chen S, Liao Y, Zhang E, Feng S, Yu S, Li LF, He WR, Li Y, Luo Y, Sun Y, Zhou M, Wang X, Munir M, Li S, Qiu HJ.
J Virol 2016 Sep 7. pii: JVI.01407-16. [Epub ahead of print] (IF 4.501)
74. Ma K, Huang MY, Guo YX, Hu GQ.
Oncol Lett 2016 Sep;12(3):1854-1860. (IF 2.311)
75. Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, Zhao D, Qiu W, Wang Y.
PLoS One 2016 Sep 1;11(9):e0161867. (IF 2.74)
76. Zhang M, Song S, Yi Z, Zhao X, Fu L, Wang L, Ma C, Mao M, Xing Y, Zhu D.
Eur J Pharmacol 2016 Oct 5;788:45-53. (IF 3.263)
77. Han Y, Zhou L, Wu T, Huang Y, Cheng Z, Li X, Sun T, Zhou Y, Du Z.
Cell Mol Neurobiol 2016 Oct;36(7):1097-107. (IF 3.606)
78. Lin X, Wu S, Wang Q, Shi Y, Liu G, Zhi J, Wang F.
Cell Mol Neurobiol 2016 Nov;36(8):1365-1375. (IF 3.606)
79. Liu Q, Li H, Wang Q, Zhang Y, Wang W, Dou S, Xiao W.
RESP RES  2016 Nov 25;17(1):159. (IF 3.751)
81. Liu X, Ren K, Suo R, Xiong SL, Zhang QH, Mo ZC, Tang ZL, Jiang Y, Peng XS, Yi GH.
J Physiol Biochem 2016 Dec;72(4):657-667. (IF 2.952)
82. Yu HP, Zhang N, Zhang T, Wang ZL, Li N, Tang HH, Zhang R, Zhang MN, Xu B, Fang Q, Wang R.
Peptides 2016 Dec;86:24-32. (IF 2.843)
83. He LX, Tong X, Zeng J, Tu Y, Wu S, Li M, Deng H, Zhu M, Li X, Nie H, Yang L, Huang F.
Inflammation 2016 Dec;39(6):1904-1917. (IF 3.212)
84. Geng H, Zhao L, Liang Z, Zhang Z, Xie D, Bi L, Wang Y, Zhang T, Cheng L, Yu D, Zhong C.
Oncol Lett 2017 Jan;13(1):469-475. (IF 2.311)
85. Xu Y, Zhao Y, Xu Y, Guan Y, Zhang X, Chen Y, Wu Q, Zhu G, Chen Y, Sun F, Wang J, Yu Y.
Cell Signal 2017 Jan;29:209-217. (IF 3.968)
86. Yu K, Ma Y, Li X, Wu X, Liu W, Li X, Shen J, Wang H.
Cell Biol Int 2017 Jan;41(1):84-92. (IF 2.571)
87. Xu Y, Zhao Y, Xu Y, Guan Y, Zhang X, Chen Y, Wu Q, Zhu G, Chen Y, Sun F, Wang J, Yu Y.
Cell Signal 2017 Jan;29:209-217. (IF 3.968)
88. Yu K, Ma Y, Li X, Wu X, Liu W, Li X, Shen J, Wang H.
Cell Biol Int 2017 Jan;41(1):84-92. (IF 2.571)
89. You N, Li J, Gong Z, Huang X, Wang W, Wang L, Wu K, Zheng L.
MOL CARCINOGEN 2017 Feb;56(2):607-624. (IF 3.825)
90. Wang H, Li C, Li J, Zhu Y, Jia Y, Zhang Y, Zhang X, Li W, Cui L, Li W, Liu Y.
Iran J Basic Med Sci 2017 Apr;20(4):408-414. (IF 2.146)
92. Huang WS, Xu FM, Zeng QZ, Liu XH, Gao XJ, Liu LX.
Biomed Environ Sci 2017 Jul;30(7):473-481. (IF 2.656)
94. Zhang M, Xin W, Yi Z, Li Y, Liu Y, Zhang H, Chen H, Chen X, Tan S, Zhu D.
J Cell Biochem 2018 Feb;119(2):1337-1345. (IF 4.237)
96. Wang T, Cheng J, Wang S, Wang X, Jiang H, Yang Y, Wang Y, Zhang C, Liang W, Feng H
Brain Res Bull 2018 Jun;140:299-310. (IF 3.37)
97. Geng B, Liang M, Qin L, Zhao W, Wang H, Wang L, Pan X, Chen X
J Cell Mol Med. 23(2):1458-1469. (IF 4.486)
98. Zhang C, Xie H, Yang Q, Yang Y, Li W, Tian H, Lu L, Wang F, Xu JY, Gao F, Wang J, Jin C, Xu G, Xu GT, Zhang J
Clin Exp Ophthalmol. 47(9):1182-1197. (IF 2.832)
99. Xin Xue, Liang Zhang, Xiang Yin, Xing-Xing Chen, Zong-Feng Chen, Chen-Xu Wang, Yu Xiang, Ming-Yong Liu, Jian-Hua Zhao
Mol Med Rep. doi: 10.3892/mmr.2020.11565. (IF 2.1)
100. Xiaolong Zhou, Qiongyu Yuan, Chen Zhang, Zhenglie Dai, Chengtao Du, Han Wang, Xiangchen Li, Songbai Yang, Ayong Zhao
Virol J. doi: 10.1186/s12985-021-01492-5. (IF 2.579)
S1901-1mg
10mg/ml×0.1ml
U0126 (MEK1/2抑制剂)
S1876-5mg
5mg
SP600125 (JNK抑制剂)
S1901-25mg
25mg
U0126 (MEK1/2抑制剂)
P0013B
100ml
RIPA裂解液(强)
S1863-5mg
5mg
SB203580 (p38 MAPK抑制剂)
QH10269S
200次
Human AMY2A qPCR Primer Pair
SD5924-25mg
25mg
PD0325901 (MEK抑制剂)
C0003
100次
细胞凋亡－Hoechst染色试剂盒
SD5951-5mg
5mg
Binimetinib (MEK抑制剂)
S1643-5mg
5mg
H-89 (PKA抑制剂)
SD5978-5mg
5mg
FR 180204 (ERK抑制剂)
S1805
2mg
PD 98, 059 (MAPKK抑制剂)