碧云天-S1883-Staurosporine (PKC抑制剂)

Staurosporine (PKC抑制剂)

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产品编号： S1883

数量：

¥ 1918.00 元

产品包装:

0.1mg 0.5mg

					产品简介
				
					使用说明
				
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Staurosporine，是一种可以通透细胞膜的蛋白激酶C(PKC)抑制剂，IC50达到0.7nM。在浓度较高时(1-20nM)，可以抑制
CDK1/cyclin B，CDK2/cyclin A，CDK4/cyclin D，CDK/p25，GSK-3β，PKA、PKG和CAMKII等蛋白激酶；在50-100nM，可以促进神经突起的生长(Neurite outgrowth)；在0.2-1μM，可以诱导细胞凋亡。Staurosporine还可以抑制肿瘤细胞中VEGF的上调。
Staurosporine分子量为466.53，分子式为C₂₈H₂₆N₄O₃，CAS Number：62996-74-1。本产品为进口分装，纯度大于98%。
Staurosporine可溶于DMSO和DMF，微溶于氯仿和甲醇，不溶于水。
本Staurosporine用DMSO配制，浓度为1mM，体积约为0.21ml×5，经过滤除菌可直接用于细胞培养。
包装清单：

产品编号	产品名称	包装
S1883	Staurosporine(PKC抑制剂,1mM)	S1882×5管
—	说明书	1份

保存条件：
-20℃避光保存。-70℃避光保存更佳。
注意事项：
本产品对人体有毒，操作时请特别小心，并注意有效防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. Staurosporine常见使用浓度范围为10-200nM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

说明书下载

相关产品请点击如下按钮：

PKC Signaling

使用本产品的文献：

1. Lv QY, Wan B, Guo LH, Zhao L, Yang Y.

In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: apoptosis and immune cell dysfunction.

Chemosphere 2015 Feb;120:621-30. (IF 5.778)

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Capsaicin alleviates abnormal intestinal motility through regulation of enteric motor neurons and MLCK activity: Relevance to intestinal motility disorders.

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Thioredoxin-1 phosphorylated at T100 is needed for its anti-apoptotic activity in HepG2 cancer cells.

Life Sci 2010;87(7-8):254-60. (IF 3.647)

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Glucocorticoid decreases airway tone via a nongenomic pathway.

RESP PHYSIOL NEUROBI 2012 Jul 31;183(1):10-4. (IF 1.591)

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Expression and Functional Analysis of Storage Protein 2 in the Silkworm, Bombyx mori.

Int J Genomics 2013;2013:145450. (IF 2.414)

7. Jiang S, Zhao L, Lu Y, Wang M, Chen Y, Tao D, Liu Y, Sun H, Zhang S, Ma Y.

Piwil2 inhibits keratin 8 degradation through promoting p38-induced phosphorylation to resist Fas-mediated apoptosis.

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9. Lv D, Shen Y, Peng Y, Liu J, Miao F, Zhang J.

Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling.

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10. Jiang H, Tong Y, Yan D, Jia S, Ostenson CG, Chen Z.

The Soybean Peptide Vglycin Preserves the Diabetic β-cells through Improvement of Proliferation and Inhibition of Apoptosis.

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11. Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y.

Delineation of platelet activation pathway of Scutellarein revealed its intracellular target as Protein Kinase C.

Biol Pharm Bull 2016;39(2):181-91. (IF 1.863)

12. Tian X, Chang L, Ma G, Wang T, Lv M, Wang Z, Chen L, Wang Y, Gao X, Zhu Y.

Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein KinaseC.

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13. Gan T, Wang Y, Zhao M, Wu J, Yang J, Peng S.

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Lysophosphatidic acid upregulates connective tissue growth factor expression in osteoblasts through theGPCR/PKC and PKA pathways.

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TRIM29 Overexpression Promotes Proliferation and Survival of Bladder Cancer Cells through NF-κBSignaling.

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HMGCR inhibits the early stage of PCV2 infection, while PKC enhances the infection at the late stage.

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