SP600125 (JNK抑制剂)
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产品编号 S1876-100mg
数量
¥ 2071.00
产品包装:
5mg 25mg 100mg
产品简介
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SP600125也称Anthrapyrazolone或1,9-Pyrazoloanthrone,是一种常用的c-Jun N-terminal kinase (JNK)的高选择性抑制剂。对于JNK1和JNK2的IC50为40nM,对于JNK3的IC50为90nM。对于JNK的选择性抑制比对于ERK1和p38-MAPK的抑制高300倍以上。在细胞中,SP600125可以显著抑制JNK介导的c-Jun磷酸化,抑制IL-2、IFN-γ、TNF-α和COX2等基因的表达。
SP600125常用于JNK信号途径(JNK signaling pathway)的研究。
SP600125的分子量为220.23,分子式为C14H8N2O,CAS Number:129-56-6。本产品纯度大于98%。
本产品为进口分装,可以溶解于DMSO(溶解度约为15mg/ml),不溶于水。溶解于DMSO配制成的储存液可以在-20度稳定保存2个月。
包装清单:

产品编号 产品名称 包装
S1876-5mg SP600125(JNK抑制剂) 5mg
S1876-25mg SP600125(JNK抑制剂) 25mg
S1876-100mg SP600125(JNK抑制剂) 100mg
说明书 1份

保存条件:
-20℃避光保存,一年有效。
注意事项:
本产品对人体有刺激性,操作时请小心,并注意适当防护以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用,不得用于临床诊断或治疗,不得用于食品或药品,不得存放于普通住宅内。
为了您的安全和健康,请穿实验服并戴一次性手套操作。 

使用说明:
1. SP600125常见使用浓度范围为1-100μM,最常见的使用浓度为10μM。具体的最佳工作浓度请参考相关文献,或根据实验目的,以及所培养的特定细胞和组织,通过实验进行摸索和优化。
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使用本产品的文献:
1. Zheng X, Cheng M, Fu B, Fan X, Wang Q, Yu X, Sun R, Tian Z, Wei H.
Cancer Res 2015 Mar 15;75(6):1080-90. (IF 9.727)
2. Jin W, Li Q, Lin Y, Lu Y, Li H, Wang L, Hu R, Ma L, Wang J, Pang T.
Cancer Lett 2011 Sep 1;308(1):81-90. (IF 7.36)
3. Zhang Z, Miao L, Lv C, Sun H, Wei S, Wang B, Huang C, Jiao B.
Cell Death Dis 2013 Jun 6;4:e657. (IF 6.304)
4. Chen L, Meng Y, Sun Q, Zhang Z, Guo X, Sheng X, Tai G, Cheng H, Zhou Y.
Cell Death Dis 2016 Aug 11;7(8):e2334. (IF 6.304)
5. Wang J, Xiao Q, Chen X, Tong S, Sun J, Lv R, Wang S, Gou Y, Tan L, Xu J, Fan C, Ding G
Cell Death Dis 2018 Feb 7;9(2):197. (IF 6.304)
6. Jiang C, Xie P, Sun R, Sun X, Liu G, Ding S, Zhu M, Yan B, Liu Q, Chen X, Zhao C
Cell Death Dis 2018 May 1;9(5):451. (IF 6.304)
7. Liu L, Wang Y, Fan H, Zhao X, Liu D, Hu Y, Kidd AR 3rd, Bao J, Hou Y.
Stem Cells 2012 Aug;30(8):1756-70. (IF 6.022)
8. Liu RP, Zou M, Wang JY, Zhu JJ, Lai JM, Zhou LL, Chen SF, Zhang X, Zhu JH.
J NEUROINFLAMM 2014 Mar 12;11:47. (IF 5.793)
9. Jiang L, Pan CL, Wang CY, Liu BQ, Han Y, Hu L, Liu L, Yang Y, Qu JW, Liu WT.
J NEUROINFLAMM 2017 Aug 31;14(1):174. (IF 5.793)
10. Qi R, Liu H, Wang Q, Wang J, Yang F, Long D, Huang J.
CELL PHYSIOL BIOCHEM 2017;44(6):2467-2475. (IF 5.5)
11. Pan C, Xing JH, Zhang C, Zhang YM, Zhang LT, Wei SJ, Zhang MX, Wang XP, Yuan QH, Xue L, Wang JL, Cui ZQ, Zhang Y, Xu F, Chen YG.
ONCOTARGET 2016 Jun 14;7(24):35562-35576. (IF 5.168)
12. Lai JM, Zhang X, Liu FF, Yang R, Li SY, Zhu LB, Zou M, Cheng WH, Zhu JH.
ONCOTARGET 2016 Jul 12;7(28):43731-43745. (IF 5.168)
13. Liu H, Xu W, Chang X, Qin T, Yin Y, Yang Q.
ONCOTARGET 2016 Jul 5;7(27):40978-40991. (IF 5.168)
14. Yu D, Geng H, Liu Z, Zhao L, Liang Z, Zhang Z, Xie D, Wang Y, Zhang T, Min J, Zhong C.
ONCOTARGET 2017 Jan 31;8(5):8791-8800. (IF 5.168)
15. Lin Y, Cong H, Liu K, Jiao Y, Yuan Y, Tang G, Chen Y, Zheng Y, Xiao J, Li C, Chen Z, Cao P
Front Immunol. 10:1132. (IF 5.085)
16. Gao MQ, Guo SB, Chen XH, Du W, Wang CB.
Acta Pharmacol Sin 2007 Jul;28(7):1007-14. (IF 5.064)
17. Gao MQ, Guo SB, Chen XH, Du W, Wang CB.
Acta Pharmacol Sin 2007 Jul;28(7):1007-14. (IF 5.064)
18. Su AR, Qiu M, Li YL, Xu WT, Song SW, Wang XH, Song HY, Zheng N, Wu ZW.
Acta Pharmacol Sin 2017 Jan 23. doi: 10.1038/aps.2016.160. [Epub ahead of print] (IF 5.064)
19. Shi X, Zhou B.
Toxicol Sci 2010;115(2):391-400. (IF 3.703)
20. Li W, Liu Y, Li XX, Yu Y, Wu JJ, Wang Q, Huo H, Wang LM, Yang L.
Planta Med 2011 Jan;77(1):27-31. (IF 2.687)
21. Gong J, Shen XH, Chen C, Qiu H, Yang RG.
Virol Sin 2011 Apr;26(2):114-22. (IF 3.242)
22. Huang X, Tong JS, Wang ZB, Yang CR, Qi ST, Guo L, Ouyang YC, Quan S, Sun QY, Qi ZQ, Huang RX, Wang HL.
Microsc Microanal 2011 Apr;17(2):197-205. (IF 3.414)
23. Xie H, Hua C, Sun L, Zhao X, Fan H, Dou H, Sun L, Hou Y.
ARTHRITIS RHEUM-US  2011 Aug;63(8):2425-35.
24. Lu X, Liu J, Hou F, Liu Z, Cao X, Seo H, Gao B.
CELL STRESS CHAPERON 2011 Sep;16(5):539-48. (IF 2.892)
26. Ma J, Zhang L, Han W, Shen T, Ma C, Liu Y, Nie X, Liu M, Ran Y, Zhu D.
J Lipid Res 2012 Jun;53(6):1093-105. (IF 4.483)
27. Song J, Shu L, Zhang Z, Tan X, Sun E, Jin X, Chen Y, Jia X.
CHEM-BIOL INTERACT 2012 Jul 30;199(1):9-17. (IF 3.723)
28. Sun Z, Yu X, Wu W, Jia D, Chen Y, Ji L, Liu X, Peng X, Li Y, Yang L, Ruan Y, Gu J, Ren S, Zhang S.
BIOCHEM BIOPH RES CO 2012 Jul 13;423(4):775-80. (IF 2.985)
29. Zhao X, Liu L, Liu D, Fan H, Wang Y, Hu Y, Hou Y.
Am J Reprod Immunol 2012 Oct;68(4):290-300. (IF 2.739)
30. Zhang X, Ding R, Zhou Y, Zhu R, Liu W, Jin L, Yao W, Gao X.
PLoS One 2013;8(3):e60781. (IF 2.74)
32. Ye L, Shi Z, Liu H, Yang X, Wang K.
Biol Trace Elem Res 2013 Jan;151(1):148-55. (IF 2.639)
34. Zhao C, Yin P, Mei C, Li N, Yao W, Li X, Qi J, Fan K, Li Z, Wang L, Shi Y, Qiu S, Fan J, Zha X.
Mol Cell Biochem 2013 Apr;376(1-2):111-9. (IF 2.795)
35. Li HJ, Guo LM, Yang LL, Zhou YC, Zhang YJ, Guo J, Xie XJ, Guo GZ.
Toxicol Lett 2013 Jun 20;220(1):35-43. (IF 3.569)
36. Li B, Dong Z, Liu H, Xia YF, Liu XM, Luo BB, Wang WK, Li B, Gao F, Zhang C, Zhang MX, Zhang Y, An FS.
Atherosclerosis 2013 Jun;228(2):370-9. (IF 3.919)
37. Hu X, Wang H, Liu J, Fang X, Tao K, Wang Y, Li N, Shi J, Wang Y, Ji P, Cai W, Bai X, Zhu X, Han J, Hu D.
Arch Dermatol Res 2013 Jul;305(5):433-45. (IF 2.339)
38. Liu Y, He G, Wang Y, Guan X, Pang X, Zhang B.
Toxicol Lett 2013 Jul 31;221(1):23-30. (IF 3.569)
39. Wu X, Mi Y, Yang H, Hu A, Zhang Q, Shang C.
Mol Cell Biochem 2013 Aug;380(1-2):249-57. (IF 2.795)
41. Wang Y, Yang Z, Meng Z, Cao H, Zhu G, Liu T, Wang X.
Int J Biol Sci 2013 Dec 22;10(1):90-102. (IF 4.858)
42. Xu L, Yu J, Zhai D, Zhang D, Shen W, Bai L, Cai Z, Yu C.
EVID-BASED COMPL ALT 2014;2014:378684. (IF 1.813)
43. Qi T, Zhang W, Luan Y, Kong F, Xu D, Cheng G, Wang Y.
Mol Cell Proteomics 2014 Jan;13(1):49-62. (IF 4.87)
44. Kong Q, Hua H, Cui A, Shao T, Song P, Jiang Y.
Int J Mol Sci 2014 Sep 15;15(9):16246-56. (IF 4.556)
45. Zhu X, Zhang J, Sun H, Jiang C, Dong Y, Shan Q, Su S, Xie Y, Xu N, Lou X, Liu S.
J Biol Chem 2014 Oct 31;289(44):30567-77. (IF 4.238)
46. Jiang S, Zhao L, Lu Y, Wang M, Chen Y, Tao D, Liu Y, Sun H, Zhang S, Ma Y.
Mol Cell Biol 2014 Nov;34(21):3928-38. (IF 3.611)
47. Ren Y, Zheng J, Yao X, Weng G, Wu L.
Int J Mol Med 2014 Nov;34(5):1430-8. (IF 3.098)
48. Li Q, Huyan T, Ye LJ, Li J, Shi JL, Huang QS.
J AGR FOOD CHEM 2014 Nov 12;62(45):10928-35. (IF 4.192)
49. Xie J, Zhang S, Hu Y, Li D, Cui J, Xue J, Zhang G, Khachigian LM, Wong J, Sun L, Wang M.
BBA-BIOMEMBRANES 2014 Dec;1842(12 Pt A):2479-88. (IF 3.411)
51. Lan B, Wan YJ, Pan S, Wang Y, Yang Y, Leng QL, Jia H, Liu YH, Zhang CZ, Cao Y.
BIOCHEM BIOPH RES CO 2015 Jan 2;456(1):434-9. (IF 2.985)
52. Wang J, Zhang L, Zhang Y, Luo M, Wu Q, Yu L, Chu H.
Toxicol In Vitro 2015 Mar;29(2):380-8. (IF 2.959)
53. He Q, Bao L, Zimering J, Zan K, Zhang Z, Shi H, Zu J, Yang X, Hua F, Ye X, Cui G.
Neuroreport 2015 May 6;26(7):416-23. (IF 1.394)
55. Lin X, Fang Q, Chen S, Zhe N, Chai Q, Yu M, Zhang Y, Wang Z, Wang J.
LEUKEMIA RES 2015 May;39(5):544-52. (IF 2.214)
57. Zhang Q, Yuan L, Zhang Q, Gao Y, Liu G, Xiu M, Wei X, Wang Z, Liu D.
Int Immunopharmacol 2015 Sep;28(1):578-87. (IF 3.943)
58. Li W, Li G, Zhang Y, Wei S, Song M, Wang W, Yuan X, Wu H, Yang Y.
Exp Cell Res 2015 Dec 10;339(2):367-79. (IF 3.383)
59. Zhou Y, Zhang S, Deng S, Dai C, Tang S, Yang X, Li D, Zhao K, Xiao X.
TOXICOL MECH METHOD 2016;26(1):11-21. (IF 2.295)
60. Qin Z, Feng J, Liu Y, Deng LL, Lu C.
TUMOR BIOL  2016 Jan;37(1):591-9. (IF 3.65)
61. Wang B, Li F, Zhang C, Wei G, Liao P, Dong N.
J THORAC CARDIOV SUR 2016 Jan;151(1):255-62. (IF 4.451)
62. Zhang C, Jia X, Wang K, Bao J, Li P, Chen M, Wan JB, Su H, Mei Z, He C.
PLoS One 2016 Jan 25;11(1):e0147405. (IF 2.74)
63. Rui W, Guan L, Zhang F, Zhang W, Ding W.
J Appl Toxicol 2016 Jan;36(1):48-59. (IF 2.997)
64. Li Z, Wang S, Zhao W, Sun Z, Yan H, Zhu J.
Mol Med Rep 2016 Feb;13(2):1709-16. (IF 2.1)
65. Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su H, Wang Y, Mei Z, He C.
BMC COMPLEM ALTERN M 2016 Feb 9;16:58. (IF 2.833)
66. Fu X, Xie FN, Dong P, Li QC, Yu GY, Xiao R.
PLoS One 2016 Feb 9;11(2):e0148819. (IF 2.74)
67. Shi M, Ren X, Wang X, Wang H, Liu G, Yuan X, Zheng S, Yu L, Pan S, Song G, Guo Q, Li L, Zhang X, Zhang Z, Ding H, Jiang G.
Int J Oncol 2016 Feb;48(2):734-46. (IF 3.899)
69. Lv M, Xia YF, Li B, Liu H, Pan JY, Li BB, Zhang C, An FS.
J Physiol Biochem 2016 Mar;72(1):71-81. (IF 2.952)
70. Tang J, Zhan L, Qin C.
MICROB PATHOGENESIS 2016 Apr;93:78-82. (IF 2.914)
71. Wang Y, Cao J, Fan Y, Xie Y, Xu Z, Yin Z, Gao L, Wang C.
Int J Mol Med 2016 Jun;37(6):1567-75. (IF 3.098)
72. Chen T, Wang Q, Li Y, Huang H, Hu W.
Exp Ther Med 2016 Jun;11(6):2413-2419. (IF 1.785)
73. Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su H, Li P, Wan JB, He C.
SCI REP-UK 2016 Jun 6;6:26064. (IF 3.998)
74. Cui Y, Lu P, Song G, Liu Q, Zhu D, Liu X.
Food Chem Toxicol 2016 Jun;92:26-37. (IF 4.679)
75. Xu L, Zhang X, Li Y, Lu S, Lu S, Li J, Wang Y, Tian X, Wei JJ, Shao C, Liu Z.
TUMOR BIOL  2016 Jul;37(7):8721-9. (IF 3.65)
76. Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y.
Toxicology 2016 Jul 1;363-364:48-57. (IF 4.099)
77. Li Q, Bao F, Zhi D, Liu M, Yan Q, Zheng X, Ren L, Cong S, Li Y, Cao G.
Lipids Health Dis 2016 Aug 11;15(1):127. (IF 2.906)
78. Li T, Zhao J, Ge J, Yang J, Song X, Wang C, Mao J, Zhang Y, Zou Y, Liu Y, Chen G.
Neurochem Res 2016 Aug;41(8):1969-81. (IF 3.038)
79. Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, Zhao D, Qiu W, Wang Y.
PLoS One 2016 Sep 1;11(9):e0161867. (IF 2.74)
80. Lin X, Wu S, Wang Q, Shi Y, Liu G, Zhi J, Wang F.
Cell Mol Neurobiol 2016 Nov;36(8):1365-1375. (IF 3.606)
82. Shi S, Zhang Y, Wen W, Zhao Y, Sun L.
Mol Med Rep 2016 Nov;14(5):4342-4348. (IF 2.1)
83. Chen L, Meng Y, Guo X, Sheng X, Tai G, Zhang F, Cheng H, Zhou Y.
Apoptosis 2016 Nov;21(11):1291-1301. (IF 4.543)
84. Xue LX, Xu ZH, Wang JQ, Cui Y, Liu HY, Liang WZ, Ji QY, He JT, Shao YK, Mang J, Xu ZX.
BIOCHEM BIOPH RES CO 2016 Nov 18;480(3):355-361. (IF 2.985)
85. Su J, Zhou H, Liu X, Nilsson J, Fredrikson GN, Zhao M.
J Cell Mol Med 2016 Dec 20.doi: 10.1111/jcmm.13033. [Epub ahead of print] (IF 4.486)
86. He LX, Tong X, Zeng J, Tu Y, Wu S, Li M, Deng H, Zhu M, Li X, Nie H, Yang L, Huang F.
Inflammation 2016 Dec;39(6):1904-1917. (IF 3.212)
87. Guo C, Yang L, Wan CX, Xia YZ, Zhang C, Chen MH, Wang ZD, Li ZR, Li XM, Geng YD, Kong LY.
Phytomedicine 2016 Dec 1;23(13):1629-1637. (IF 4.268)
88. Geng H, Zhao L, Liang Z, Zhang Z, Xie D, Bi L, Wang Y, Zhang T, Cheng L, Yu D, Zhong C.
Oncol Lett 2017 Jan;13(1):469-475. (IF 2.311)
89. Yin X, Zhou L, Han F, Han J, Zhang Y, Sun Z, Zhao W, Wang Z, Zheng L.
J Atheroscler Thromb 2017 Jan 1;24(1):55-67. (IF 3.876)
90. Zhu Y, Jiang Y, Shi L, Du L, Xu X, Wang E, Sun Y, Guo X, Zou B, Wang H, Wang C, Sun L, Zhen Y.
Biomed Pharmacother 2017 Jan 8;87:527-538. (IF 4.545)
91. Li Y, Hu N, Yang D, Oxenkrug G, Yang Q.
FEBS J 2017 Jan 24.doi: 10.1111/febs.14026. [Epub ahead of print] (IF 4.392)
92. Xu Y, Zhao Y, Xu Y, Guan Y, Zhang X, Chen Y, Wu Q, Zhu G, Chen Y, Sun F, Wang J, Yu Y.
Cell Signal 2017 Jan;29:209-217. (IF 3.968)
93. You F, Li Q, Jin G, Zheng Y, Chen J, Yang H.
BMC Neurosci 2017 Jan 12;18(1):12. (IF 2.811)
94. Xu Y, Zhao Y, Xu Y, Guan Y, Zhang X, Chen Y, Wu Q, Zhu G, Chen Y, Sun F, Wang J, Yu Y.
Cell Signal 2017 Jan;29:209-217. (IF 3.968)
96. Ma T, Chen X, Ouyang H, Liu X, Ouyang T, Peng Z, Yang X, Chen F, Pang D, Bai J, Ren L.
Virus Res 2017 Feb 2;229:41-47. (IF 2.934)
99. Xue LX, Liu HY, Cui Y, Dong Y, Wang JQ, Ji QY, He JT, Yao M, Wang YY, Shao YK, Mang J, Xu ZX.
Neural Regen Res 2017 May;12(5):779-786. (IF 3.171)
100. Zeng L, Rong XF, Li RH, Wu XY.
Mol Med Rep 2017 May;15(5):2853-2858. (IF 2.1)
101. Luo L, Xi C, Xu T, Zhang G, Qun E, Zhang W.
Eur J Pharmacol 2017 Jul 15;807:109-116. (IF 3.263)
102. Liu Y, Feng J, Zhao M, Wu J, Fan J, Wen Q, Xu J, Zhang J, Fu S, Wang B, Lu Y, Xiong K, Xiang L, Zhang Y, Yang L.
Oncol Lett 2017 Aug;14(2):1790-1794. (IF 2.311)
103. Xu L, Fu Y, Li Y, Han X.
CANCER CHEMOTH PHARM 2017 Aug;80(2):235-242. (IF 2.967)
104. Li Y, Wang Y, Wu Y, Wang B, Chen X, Xu X, Chen H, Li W, Xu X.
Dev Comp Immunol 2017 Aug;73:21-26. (IF 3.192)
105. Wang H, Yu Q, Nie SP, Xiang QD, Zhao MM, Liu SY, Xie MY, Wang SQ.
Food Chem Toxicol 2017 Oct;108(Pt B):478-485. (IF 4.679)
106. Wang J, Huang J, Wang L, Chen C, Yang D, Jin M, Bai C, Song Y.
J Thorac Dis 2017 Nov;9(11):4398-4412. (IF 2.046)
107. Jiang Y, Ji F, Liu Y, He M, Zhang Z, Yang J, Wang N, Zhong C, Jin Q, Ye X, Chen T.
Oncol Rep 2017 Dec;38(6):3668-3676. (IF 3.417)
108. Liu Z, Wang J, Xing W, Peng Y, Huang Y, Fan X.
Mol Med Rep 2018 Feb;17(2):2549-2556. (IF 2.1)
109. Zhang X, Zhang M, Xiao B, Jiao W, Zhang S, Zhang X
Oncol Rep 2018 Mar;39(3):1423-1431. (IF 3.417)
110. Yin L, Pang G, Niu C, Habasi M, Dou J, Aisa HA.
Int J Mol Med 2018 Mar 2;3727-3735. (IF 3.098)
112. Zhou ZY, Xiao Y, Zhao WR, Zhang J, Shi WT, Ma ZL, Ye Q, Chen XL, Tang N, Tang JY
Phytomedicine. 65:153083. (IF 4.268)
113. Wei Liu, Yi Chai, Libo Hu, Junhua Wang, Xin Pan, Hongyu Yuan, Zitong Zhao, Yongmei Song, Yuqi Zhang
Onco Targets Ther. doi: 10.2147/OTT.S243953.
114. Qiu-Yang Zhang, Shu-Ya Tao, Chang Lu, Jing-Jing Li, Xiu-Miao Li, Jin Yao, Qin Jiang, Biao Yan
Mol Med Rep. doi: 10.3892/mmr.2020.11056. (IF 2.1)
115. Mengfei Cao, Ziqi Mao, Meiling Peng, Qianru Zhao, Xia Sun, Jinchuan Yan, Wei Yuan
Mol Cell Endocrinol. doi: 10.1016/j.mce.2020.110990. (IF 3.871)
116. Xiaolong Zhou, Qiongyu Yuan, Chen Zhang, Zhenglie Dai, Chengtao Du, Han Wang, Xiangchen Li, Songbai Yang, Ayong Zhao
Virol J. doi: 10.1186/s12985-021-01492-5. (IF 2.579)
117. Yukang Wen, Zhengkun Chen, Yaqin Tian, Mei Yang, Qingshuang Dong, Yujiao Yang, Honglei Ding
Vet Res. doi: 10.1186/s13567-022-01074-5. (IF 3.357)
118. Zhe Huang, Yan Yang, Xianming Fan, Wenzhe Ma
Front Pharmacol. doi: 10.3389/fphar.2022.952677. (IF 4.225)