碧云天-S1643-1mg-H-89 (PKA抑制剂)

H-89 (PKA抑制剂)

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产品编号： S1643-1mg

数量：

¥ 146.00 元

产品包装:

10mg/ml×0.1ml 5mg 25mg 100mg

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H-89也称H89，全称为N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide·2HCl hydrate，是一种常用的PKA抑制剂。H-89可以通透细胞，可以选择性抑制cAMP、cGMP依赖的蛋白激酶PKA、PKG和PKCμ，但对于PKA的选择性抑制作用更强。
H-89分子量为519.28，分子式为C₂₀H₂₀BrN₃O₂S·2HCl，CAS Number：127243-85-0。本产品纯度大于98%。
本H-89为进口分装，其中10mg/ml包装产品用DMSO配制，浓度接近20mM，共0.1ml。5mg，25mg和100mg包装为粉末装。
包装清单：

产品编号	产品名称	包装
S1643-1mg	H-89 (PKA抑制剂)	10mg/ml×0.1ml
S1643-5mg	H-89 (PKA抑制剂)	5mg
S1643-25mg	H-89 (PKA抑制剂)	25mg
S1643-100mg	H-89 (PKA抑制剂)	100mg
—	说明书	1份

保存条件：
-20℃保存，一年有效。
注意事项：
本产品对人体有害，操作时请小心，并注意有效防护以避免直接接触人体或吸入体内。
本H-89在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：
1. H-89常见使用浓度范围为10-30μM，也有报道在1-50μM范围内使用。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

说明书下载

相关产品请点击如下按钮：

MAPK/Erk in GPCR Signaling

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1. Shen C, Li X, Rasooly A, Guo L, Zhang K, Yang M.

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